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Research, Clinical Trials, Drug Resistance and Safety for Cancer Immunotherapy in Head and Neck Cancers and Brain Tumors
Head and neck cancers (HNCs) and brain tumors continue to be fatal diseases in most countries of the world. In the past decade, cancer immunotherapy has emerged as a promising therapeutic strategy and achieved unprecedented bench-to-bedside clinical success in the field of oncology. Different from traditional surgery, chemotherapy, and radiotherapy, the current cancer immunotherapy aims to recover or enhance the immune system of a patient, to recognize and eliminate cancerous cells from the primary tumor and metastases. Numerous immunotherapy strategies, in particular immune checkpoint inhibitors, adoptive cellular therapies, and cancer vaccines, are under pre-clinical investigations or in o...
MMP3 is a Non-invasive Biomarker of Rejection in Skin-bearing Vascularized Composite Allotransplantation
Abstract: Background: There is unmet need for non-invasive immunomonitoring to improve diagnosis and treatment of acute rejection in vascularized composite allotransplantation (VCA). Circulating matrix metalloproteinase 3 (MMP3) was described as a candidate non-invasive biomarker to predict treatment response to acute rejection in clinical VCA. However, larger validation studies are yet to be reported to allow for more definitive conclusions. Methods: We retrospectively measured MMP3 levels using ELISA in a total of 140 longitudinal serum samples from six internal and three external face transplant recipients, as well as three internal and seven external upper extremity transplant recipients...
Inside Arabic Music
What makes hundreds of listeners cheer ecstatically at the same instant during a live concert by Egyptian diva Umm Kulthum? What is the unspoken language behind a taqsim (traditional instrumental improvisation) that performers and listeners implicitly know? How can Arabic music be so rich and diverse without resorting to harmony? Why is it so challenging to transcribe Arabic music from a recording? Inside Arabic Music answers these and many other questions from the perspective of two "insiders" to the practice of Arabic music, by documenting a performance culture and a know-how that is largely passed on orally. Arabic music has spread across the globe, influencing music from Greece all the w...
Patterns of Political Leadership
Study of the relationship between the characteristics of governing elites and inter-state conflict in the Middle East.
