Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
A Noelin-organized Extracellular Network of Proteins Required for Constitutive and Context-dependent Anchoring of AMPA-receptors
Abstract: Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution and dynamics of AMPARs in the plasma membrane are controlled by Noelins, a three-member family of conserved secreted proteins expressed throughout the brain in a cell-type-specific manner. Noelin tetramers tightly assemble with the extracellular domains of AMPARs and interconnect them in a network-like configuration with a variety of secreted and membrane-anchored proteins including Neurexin1, Neuritin1, and Seizure 6-like. Knock out of Noelins1-3 profoundly reduced AMPARs in synapses onto excitatory and inhibitory (inter)neurons, decreased their density and clustering in dendrites, and abolished activity-dependent synaptic plasticity. Our results uncover an endogenous mechanism for extracellular anchoring of AMPARs and establish Noelin-organized networks as versatile determinants of constitutive and context-dependent neurotransmission
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Life Of Galileo
This Student Edition of Brecht's classic dramatisation of the conflict between free enquiry and official ideology features an extensive introduction and commentary that includes a plot summary, discussion of the context, themes, characters, style and language as well as questions for further study and notes on words and phrases in the text. It is the perfect edition for students of theatre and literature Along with Mother Courage, the character of Galileo is one of Brecht's greatest creations, immensely live, human and complex. Unable to resist his appetite for scientific investigation, Galileo's heretical discoveries about the solar system bring him to the attention of the Inquisition. He i...
Understanding Dialogue
Using a novel model, this book investigates the psycholinguistics of dialogue, approaching language use as a social activity.
Innovation, Collective Intelligence and Resiliency in Healthcare Organizations
Resilience in healthcare organizations is a complex issue, involving all stakeholders in the healthcare field. It is a highly topical issue, even more so in the wake of the recent health crisis. This book explores the impact of collective intelligence on the resilience of these organizations, and the role played by innovation. Health organizations comprise the structures and systems involved in treating patients, as well as healthcare professionals with medical, social or medico-social expertise, along with institutional and administrative players in the field. Innovation, Collective Intelligence and Resiliency in Healthcare Organizations alternates between theoretical readings and illustrative case studies. Their diversity is the result of their contributors: university researchers, institutional players from healthcare authorities, practicing caregivers in hospital structures or healthcare coordination support systems, and managers of healthcare structures and systems.
The Medical Examiner
None
