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Los eufemismos
Clara, la protagonista de esta novela, podría dividir su vida en dos partes: antes de la llegada de los eufemismos era una estudiante de posgrado con una relación estable y proyectos profesionales. Un día recibe una llamada en la que le dicen que su madre se encuentra "muy nerviosa" —se trata del primer eufemismo— y entonces todo cambia, tal vez de manera irreparable. ¿Qué pasa cuando la figura materna se desmorona?, ¿cómo enfrentarlo con humor, ironía y agudeza? En cuatro días, Clara deberá hacer cuentas con su pasado sentimental, la historia de persecución política y exilio de sus padres argentinos y con sus proyectos de vida, para tomar una decisión que le permita enfrentar el futuro cercano y decidir cuál es su lugar en el mundo —si es que tal cosa existe—. El poderoso lenguaje de Ana Negri se adentra en los lugares que azarosamente habitamos y el uso esencial de las palabras.
DNA-targeting Molecules as Therapeutic Agents
There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Ce que tomber veut dire
« Votre mère est très nerveuse. » C’est ainsi que tout a basculé dans la vie de Clara. Un premier accroc dans le cours des jours qui depuis n’a cessé de s’élargir, comme les fissures dans la santé mentale de sa mère, clandestine en Argentine pendant la dictature, puis exilée au Mexique, qui fume cigarette sur cigarette au milieu des fantômes de son passé, le regard vide... Clara est la seule à pouvoir aider sa mère à obtenir la réparation promise par l’État argentin. Trentenaire pragmatique, mais paumée, partagée entre la tendresse et l’agacement, entre le Mexique et l’Argentine, elle s’efforce de s’occuper au mieux d’une figure maternelle tombée en morc...
Textbook of Drug Design and Discovery
Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal che...
Colonialism and Culture
Iris Zavala argues that Hispanic modernism is an emancipatory narrative of self-representation. Out of Cuba's struggles against Spanish and U.S. colonialism, modernism emerged among the Hispanic intelligentsia as an attempt to create a collective narrative rejecting colonial cultural patterns. Hispanic modernism crusaded for a cosmopolitanism opposed to colonialism. The work of José MartÃ, Rubén DarÃo, Valle-Inclán, Unamuno and Julián del Casal rejects a hegemonic idea of progress and the imposition of alien political and cultural practices. Through a poetics of negation, they generated a revolutionary social and artistic awakening that resulted in the unprecedented cultural achievments of Hispanic modernism.
Sunset
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Civil Societies and Social Movements
This volume offers an historical and comparative overview of the literature, theory, practices and critiques of what has been variously labelled 'global' or 'transnational' civil society, which includes a broad range of non-state actors, political, social and economic. The volume includes an introductory essay that historicizes and problematizes the relationship of society to state and market and contextualizes the pieces in the volume, while locating the literature in relationship to international relations, political science and sociology.
Cuerpo contra cuerpo
"En literatura el orden de los factores altera irremediablemente el producto, frase recurrente en mis escritos, postulado que de manera flagrante se verifica en esta antología, esta compilación ordenada por la mirada joven y sabia de Ana Negri, que ha reunido varios de mis ensayos de manera novedosa e iluminada. A lo largo de mi obra, me he preocupado por recuperar cuerpos, el de Malinche, la lengua o intérprete de Cortés durante la conquista de México; el de Santa, la prostituta protagonista de la novela del mismo nombre de Federico Gamboa, vendido a retazos como en las carnicerías se vendía la carne de las vacas; el cuerpo de los mutilados en la India; el de los asesinados y cremado...
Ramifications
The memories we return to most frequently are the most inaccurate, the least faithful to reality... This is the tragic realisation made by the narrator of Ramifications as he tries to make sense of the defining event of his childhood: the disappearance of his mother to join the Zapatista uprising that shook Mexico in 1994. Left behind with an emotionally distant father who is singularly unqualified to raise him, and an older sister who only wants to get on with being a teenager, he takes refuge in strange rituals that isolate him from his peers: favouring the left-hand side of his body, trying to tear leaves into perfect halves, obsessively shaping origami figures. Now, two decades older and...
