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Science and Engineering in High-Throughput Biology Including a Theory on Parkinson's Disease
Biology is shifting from its data-poor origins to a quantitative data, high-throughput regime. Accompanying this change is an increasing technical capacity to engineer biological constructs. This book is about theory in this new context for the Life Sciences. Three articles, each preceded by an explanatory introduction, are presented. They propose: * A framework for prediction in this new data-rich regime. * A theory on the systemic nature and hematopoietic origin of Parkinson's Disease. * An approach to engineering design in the biological context, in particular in Synthetic Biology.
New Trends in Cross-Coupling
Following on from its recognition in the 2010 Nobel Prize for Chemistry, contributors from across the globe present the latest cross-coupling trends in both academia and industry.
Extracellular Vesicles
Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field. Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs. Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.
Molecular Targets of CNS Tumors
Molecular Targets of CNS Tumors is a selected review of Central Nervous System (CNS) tumors with particular emphasis on signaling pathway of the most common CNS tumor types. To develop drugs which specifically attack the cancer cells requires an understanding of the distinct characteristics of those cells. Additional detailed information is provided on selected signal pathways in CNS tumors.
Organozinc Derivatives and Transition Metal Catalysts
Organozinc reagents are less reactive than Grignard reagents but they are much more chemoselective. Since the Negishi cross-coupling reaction developed by Ei-ichi Negishi, who was awarded the Nobel Price in chemistry in 2010, a number of cross-coupling reactions involving organozinc derivatives and transition metal catalysts (Pd, Ni, Fe, Co, Cu, ...) has been tuned up to form C-C bonds. This book on "Organozinc derivatives and transition metal catalysts" has been written by experts in the field and is a complement to the book entitled "Grignard reagents and transition metal catalysts" (a De Gruyter book, edited by J. Cossy). Grignard reagents or organozinc reagents, that is the question? From a given substrate, what is the best organometallic reagent and the best transition metal to form a C-C bond by using a cross-coupling reaction? The solution might be found in these two books.
Advances in Simulation and Digital Human Modeling
This book provides readers with a timely snapshot of modeling and simulation tools, including virtual and mixed-reality environment, for human factors research. It covers applications in healthcare and physical ergonomics, military and transportation systems, industrial monitoring, as well as economics and social sciences. Based on the AHFE 2021 International Conference on Human Factors and Simulation and the AHFE 2021 International Conference on Digital Human Modeling and Applied Optimization, held virtually on 25–29 July, 2021, from USA, the book offers a unique resource for modelling and simulation researchers seeking insights into human factors research and to human factors experts seeking reliable computational tools.
Human Aspects of IT for the Aged Population. Design for the Elderly and Technology Acceptance
This two-volume set LNCS 11592 and 11593 constitutes the refereed proceedings of the 5th International Conference on Human Aspects of IT for the Aged Population, ITAP 2019, held in July 2019 as part of HCI International 2019 in Orlando, FL, USA. HCII 2019 received a total of 5029 submissions, of which 1275 papers and 209 posters were accepted for publication after a careful reviewing process. The 86 papers presented in these two volumes are organized in topical sections named: Design with and for the Elderly, Aging and Technology Acceptance, Aging and the User Experience, Elderly-Specific Web Design, Aging and Social Media, Games and Exergames for the Elderly, Ambient Assisted Living, Aging, Motion, Cognition, Emotion and Learning.
Current Challenges for the Aquatic Products Processing Industry
This book offers a state-of-the-art analysis on the main challenges facing the aquatic products processing industry. The topics explored are particularly relevant to the issues faced by European consumers and processors, but the information provided within this book can be widely extrapolated. This book should be helpful for processors, fish traders, consumers, scientists and students. The first chapter is dedicated to the sociological definition of "fish" and consumers’ perceptions. The following chapters deal with the notions of quality sensu lato, biological risks and their control, as well as the risks linked to the pollution of oceans and ecosystems by microplastics. Two types of processes and processed products – smoked fish and surimi products – which are of great economic importance to the European market, are also presented. The process of adding value to co-products, including the "blue biorefinery" and the innovative pH-shift technology are also covered in this book.
Amination and Formation of sp2 C-N Bonds
Palladium-Catalyzed sp2C–N Bond Forming Reactions: Recent Developments and Applications. Metal-catalyzed C(sp2)-N bond formation.- Recent Developments in Recyclable Copper Catalyst Systems for C−N Bond Forming Cross-Coupling Reactions Using Aryl Halides and Arylboronic Acids. Assembly of N-containing heterocycles via Pd and Cu-catalyzed C-N bond formation reactions. Copper-Catalyzed C(aryl)-N Bond Formation.
