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Predicting Antimicrobial Resistance in Pseudomonas Aeruginosa with Machine Learning-enabled Molecular Diagnostics
Abstract: Limited therapy options due to antibiotic resistance underscore the need for optimization of current diagnostics. In some bacterial species, antimicrobial resistance can be unambiguously predicted based on their genome sequence. In this study, we sequenced the genomes and transcriptomes of 414 drug-resistant clinical Pseudomonas aeruginosa isolates. By training machine learning classifiers on information about the presence or absence of genes, their sequence variation, and expression profiles, we generated predictive models and identified biomarkers of resistance to four commonly administered antimicrobial drugs. Using these data types alone or in combination resulted in high (0.8-...
European Surveillance of Clostridium Difficile Infections
The objectives for the surveillance of CDIs are: - to estimate the incidence of CDIs in European acute care hospitals - to assess the burden of CDIs (including recurrent CDI cases) in European acute care hospitals - to provide participating hospitals with a standardised tool to measure and compare their own incidence rates with those observed in other participating hospitals - to assess adverse outcomes of CDIs including death - to describe the epidemiology of C. difficile at the local, national and European level, in terms of factors such as antibiotic susceptibility, PCR ribotype, presence of Clostridium difficile toxin A (TcdA), Clostridium difficile toxin B (TcdB) and binary toxin, morbidity and mortality of infection, and the detection of new/emerging types.
European Surveillance of Clostridium Difficile Infections
The objectives for the surveillance of CDIs are: - to estimate the incidence of CDIs in European acute care hospitals - to assess the burden of CDIs (including recurrent CDI cases) in European acute care hospitals - to provide participating hospitals with a standardised tool to measure and compare their own incidence rates with those observed in other participating hospitals - to assess adverse outcomes of CDIs including death- to describe the epidemiology of C. difficile at the local, national and European level, in terms of factors such as antibiotic susceptibility, PCR ribotype, presence of Clostridium difficile toxin A (TcdA), Clostridium difficile toxin B (TcdB) and binary toxin, morbidity and mortality of infection, and the detection of new/emerging types.
EMerGE-NeT
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Warfare Beneath the Waves
The longest continuous military campaign of World War II, the Battle of the Atlantic is widely considered one of the most complex naval battles in history. Between 1939 and 1945, German U-Boats and warships, together with the Luftwaffe, fought against the Royal Navy, the Royal Canadian Navy, the United States Navy and convoys of Allied merchant ships in a series of devastating battles. In Warfare Beneath The Waves, eminent naval historian Axel Niestlé focuses on three particular convoy battles that took place during this period: the German attacks on Allied Convoy SC 7 in October 1940, on Allied Convoy SC 118 in February 1943 and on Allied Convoys JW 66 and RA 66 in April and May 1945. Nies...
Africa and the War on Drugs
Nigerian drug lords in UK prisons, khat-chewing Somali pirates hijacking Western ships, crystal meth-smoking gangs controlling South Africa's streets, and narco-traffickers corrupting the state in Guinea-Bissau: these are some of the vivid images surrounding drugs in Africa which have alarmed policymakers, academics and the general public in recent years. In this revealing and original book, the authors weave these aspects into a provocative argument about Africa's role in the global trade and control of drugs. In doing so, they show how foreign-inspired policies have failed to help African drug users but have strengthened the role of corrupt and brutal law enforcement officers, who are tasked with halting the export of heroin and cocaine to European and American consumer markets. A vital book on an overlooked front of the so-called war on drugs.
FF Communications
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Arctic Bibliography
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