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Predicting Antimicrobial Resistance in Pseudomonas Aeruginosa with Machine Learning-enabled Molecular Diagnostics
Abstract: Limited therapy options due to antibiotic resistance underscore the need for optimization of current diagnostics. In some bacterial species, antimicrobial resistance can be unambiguously predicted based on their genome sequence. In this study, we sequenced the genomes and transcriptomes of 414 drug-resistant clinical Pseudomonas aeruginosa isolates. By training machine learning classifiers on information about the presence or absence of genes, their sequence variation, and expression profiles, we generated predictive models and identified biomarkers of resistance to four commonly administered antimicrobial drugs. Using these data types alone or in combination resulted in high (0.8-...
Reader's Guide to the Social Sciences
This 2-volume work includes approximately 1,200 entries in A-Z order, critically reviewing the literature on specific topics from abortion to world systems theory. In addition, nine major entries cover each of the major disciplines (political economy; management and business; human geography; politics; sociology; law; psychology; organizational behavior) and the history and development of the social sciences in a broader sense.
Bacterial Cell Walls and Membranes
This book provides an up-to-date overview of the architecture and biosynthesis of bacterial and archaeal cell walls, highlighting the evolution-based similarities in, but also the intriguing differences between the cell walls of Gram-negative bacteria, the Firmicutes and Actinobacteria, and the Archaea. The recent major advances in this field, which have brought to light many new structural and functional details, are presented and discussed. Over the past five years, a number of novel systems, e.g. for lipid, porin and lipopolysaccharide biosynthesis have been described. In addition, new structural achievements with periplasmic chaperones have been made, all of which have revealed amazing details on how bacterial cell walls are synthesized. These findings provide an essential basis for future research, e.g. the development of new antibiotics. The book’s content is the logical continuation of Volume 84 of SCBI (on Prokaryotic Cytoskeletons), and sets the stage for upcoming volumes on Protein Complexes.
Multiprojektmanagement im Krankenhaus
Das Multiprojektmanagement als übergeordneter Rahmen beinhaltet neben der erfolgreichen Durchführung von Einzelprojekten die Planung, Kontrolle und Steuerung einer gesamten Projektlandschaft auch die nachhaltige Etablierung – unterstützt durch den Aufbau von organisationalen Kompetenzen. Monika Harsch erläutert eine umfassende krankenhausspezifische Konzeption eines Multiprojektmanagements. Dafür nutzt sie bereits bestehende wissenschaftlich fundierte Konzepte, entwickelt sie weiter und bezieht spezifische Anforderungen für das Krankenhaus mit ein. Grundlage der Konzeption sind die Ergebnisse einer deutschlandweiten Befragung von Mitarbeitern und Geschäftsführern von Krankenhäusern zum Stand des gegenwärtigen Projektmanagements und zur Bedeutung von Elementen des Multiprojektmanagements.
Information Technology Investment
From the individual to the largest organization, everyone today has to make investments in IT. Making a smart investment that will best satisfy all the necessary decision-making criteria requires careful and inclusive analysis. This textbook provides an up-to-date, in-depth understanding of the methodologies available to aid in this complex process of multi-criteria decision-making. It guides readers on the process of technology acquisition ? what methods to use to make IT investment decisions, how to choose the technology and justify its selection, and how the decision will impact the organization.Unique to this textbook are both financial investment models and more complex decision-making ...
Modeling Techniques in Predictive Analytics
To succeed with predictive analytics, you must understand it on three levels: Strategy and management Methods and models Technology and code This up-to-the-minute reference thoroughly covers all three categories. Now fully updated, this uniquely accessible book will help you use predictive analytics to solve real business problems and drive real competitive advantage. If you’re new to the discipline, it will give you the strong foundation you need to get accurate, actionable results. If you’re already a modeler, programmer, or manager, it will teach you crucial skills you don’t yet have. Unlike competitive books, this guide illuminates the discipline through realistic vignettes and int...
Marketing Data Science
Now, a leader of Northwestern University's prestigious analytics program presents a fully-integrated treatment of both the business and academic elements of marketing applications in predictive analytics. Writing for both managers and students, Thomas W. Miller explains essential concepts, principles, and theory in the context of real-world applications. Building on Miller's pioneering program, Marketing Data Science thoroughly addresses segmentation, target marketing, brand and product positioning, new product development, choice modeling, recommender systems, pricing research, retail site selection, demand estimation, sales forecasting, customer retention, and lifetime value analysis. Star...
