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IGF1R Expression by Adult Oligodendrocytes is Not Required in the Steady-state But Supports Neuroinflammation
Abstract: In the central nervous system (CNS), insulin-like growth factor 1 (IGF-1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti-apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work also suggests that IGF-1 protects ODCs from cell death and enhances remyelination in models of toxin-induced and autoimmune demyelination. However, since evidence remains controversial, the therapeutic potential of IGF-1 in demyelinating CNS conditions is unclear. To finally shed light on the function of IGF1-signaling for ODCs, we deleted insulin-like growth factor 1 receptor (IGF1R) specifically in mature ODCs of the mouse. We found tha...
Digital Mammography
Digital Radiography has been ? rmly established in diagnostic radiology during the last decade. Because of the special requirements of high contrast and spatial resolution needed for roentgen mammography, it took some more time to develop digital m- mography as a routine radiological tool. Recent technological progress in detector and screen design as well as increased ex- rience with computer applications for image processing have now enabled Digital Mammography to become a mature modality that opens new perspectives for the diag- sis of breast diseases. The editors of this timely new volume Prof. Dr. U. Bick and Dr. F. Diekmann, both well-known international leaders in breast imaging, have...
100 Atmospheres
100 Atmospheres is an invitation to think differently. Through speculative, poetic, and provocative texts, thirteen writers and artists have come together to reflect on human relationships with other species and the planet.
Building Shanghai
Shanghai's illustrious history and phenomenal future is celebrated in this book, which examines the evolution of the city's architecture and urban form in order to contextualise the challenges facing the city today. The physical legacies that reflect Shanghai's uniqueness historically and contemporarily are examined chronologically using specific case studies of exemplary architecture interwoven in a compelling narrative that unlocks the many mysteries surrounding this amazing metropolis. Some of the most influential colonial architecture in the world, outstanding examples of Modernism and Art Deco, and an exceptional selection of eclectic and vernacular architecture reflecting Shanghai's many adopted cultures are revealed. This is the first book ever to examine this remarkable subject in a manner that is both comprehensive and captivating in its written content and stunningly illustrated with over 300 archive and contemporary photographs and maps.
Our National Parks
First published in 1901, “Our National Parks” is a fantastic guide to the wild mountain forest reservations and national parks of the United States, exploring their beauty and usefulness in an attempt to encourage contemporary readers to go out and enjoy the natural wonders of North America. John Muir (1838–1914) was an influential Scottish-American naturalist, environmental philosopher, botanist, zoologist, author, and glaciologist who famously fought to preserve wilderness in the United States of America. Muir's work describing his adventures in nature have been read by millions the world over and his activism has helped to conserve such important places of natural beauty as the Yose...
Migrating Borders and Moving Times
Migrating borders and moving timesanalyses migrant border crossings in relation to their everyday experiences of time and connects these to wider social and political structures. Sometimes border crossing takes no more than a moment; sometimes hours; some crossers find themselves in the limbo of detention; for others, the crossing lasts a lifetime to be interrupted only by death. Borders not only define separate spaces, but different temporalities. This book provides both a single interpretative frame and a novel approach to border crossing: an analysis of the reconfiguration of memory, personal and group time that follows the migrants' renegotiation of cross-border space and recalibrations of temporality.
The Young Vermeer
Johannes Vermeer (1632-1675) is world-famous for his scenes of daily life, such as a kitchen maid pouring milk, a woman having a music lesson, or a lady writing a letter. However, when Vermeer began painting around the age of 21, he focused primarily on traditional subjects derived from the Bible and classical mythology. Not only do these early works differ greatly from his later paintings in terms of subject matter, they also differ in style.The exhibition unites three paintings from the beginning of Vermeer's artistic career: the Mauritshuis' Diana and her nymphs of c. 1653-1654, is joined by Christ in the house of Martha and Mary (c. 1655) from the National Gallery of Scotland in Edinburgh, and The Procuress (1656) from the Staatliche Kunstsammlungen in Dresden. These three paintings afford an image of the artist seeking his own style. All three paintings have recently been restored."
Encyclopedia of Water Politics and Policy in the United States
Water has had an immeasurable impact on the history and growth of the United States. As an essential element of life water has been and remains a constant source of conflict and controversy as different constituencies fight for limited resources. The Encyclopedia of Water Politics and Policy in the United States is the most comprehensive reference source available that analyzes water-related issues in America. A diverse group of over 100 scholars have provided their research and analysis of why water is so significant by tracing its impact on issues like national and state boundaries, western migration, urbanization, and the economy. This volume chronicles the origins of present-day water pr...
Breast Imaging
This book constitutes the refereed proceedings of the 13th International Workshop on Breast Imaging, IWDM 2016, held in Malmö, Sweden, in June 2016. The 35 revised full papers and 50 revised poster papers presented together with 6 invited talks were carefully reviewed and selected from 89 submissions. The papers are organized in topical sections on screening; CAD; mammography, tomosynthesis, and breast CT; novel technology; density assessment and tissue analysis; dose and classification; image processing, CAD, breast density, and new technology; contrast-enhanced imaging; phase contrast breast imaging; simulations and virtual clinical trials.
