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IGF1R Expression by Adult Oligodendrocytes is Not Required in the Steady-state But Supports Neuroinflammation
Abstract: In the central nervous system (CNS), insulin-like growth factor 1 (IGF-1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti-apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work also suggests that IGF-1 protects ODCs from cell death and enhances remyelination in models of toxin-induced and autoimmune demyelination. However, since evidence remains controversial, the therapeutic potential of IGF-1 in demyelinating CNS conditions is unclear. To finally shed light on the function of IGF1-signaling for ODCs, we deleted insulin-like growth factor 1 receptor (IGF1R) specifically in mature ODCs of the mouse. We found tha...
Magic of Sabrina the Teenage Witch
Sabrina the Teenage Witch, the most iconic magical character in comic books if not all of pop culture, is back with a bevy of spell-binding tales, featuring the classic ensemble of Salem the cat, Harvey, and Sabrina’s two bewitching aunts Hilda and Zelda, as well as some new friends and an all-new love interest. With stories written by Bill Golliher and illustrated by award winning artist Holly G!, Sabrina the Teenage Witch is sure to cast her spell on you!
Sabrina the Teenage Witch: The Magic Within 2
The magic continues in SABRINA THE TEENAGE WITCH: THE MAGIC WITHIN 2! Sabrina Spellman’s life is intense. On top of the usual stresses of being a teenager, she’s a witch! And that means two schools and twice the work, from her Mortal Realm high school and the Magic Realm’s Charm School. It should be simpler. But in addition to a regular spelling bee, she has to study for a magical spell-ing bee. She’s finally dating her childhood sweetheart-—but he doesn’t know she’s a witch! She also has a crush on a cute young wizard-—but he’s dating her best friend! On top of the drama, Sabrina keeps being dragged into the middle of strange and dangerous events in the Magic Realm. Written and illustrated by acclaimed artist Tania del Rio, THE MAGIC WITHIN 2 is the second collection of Archie's critically praised American manga!
Sabrina The Teenage Witch (2019-) #4
Sabrina’s worlds collide as the town of Greendale becomes engulfed in a literal witch hunt—putting Sabrina’s family and her secrets right in the crosshairs. But the monsters plaguing the town are not exactly what they seem and it’s up to Sabrina to save the town from itself, while clearing the name of witches everywhere. But what will be the price? Sabrina’s got everything riding on her “fresh start” in Greendale but doing the right thing might mean losing all she’s come to hold most dear.
Sabrina: Something Wicked
You demanded it: Volume Two of the critically-acclaimed Sabrina the Teenage Witch series by Kelly Thompson and Veronica & Andy Fish! Sabrina saved the day--saved her friends, her family--the whole town of Greendale really, and she should be riding high. But things are never quite that simple. She's trapped in a love triangle, she's having trouble balancing the mortal and witch parts of herself, oh yeah, and she's being blackmailed. As if all that wasn't enough, while trying to help Radka and Ren with their...supernatural problem, her aunts suddenly starting to look like people she can't trust. What's a teen witch to do?!
Monster-Sized Chilling Adventures of Sabrina
Just in time for Part 2 of Netflix’s hit Chilling Adventures of Sabrina, this special 3-in-1 comic collects issues #6 – #8 of the ongoing comic book series by Roberto Aguirre-Sacasa and Robert Hack, complete with an all-new cover!
Pep Digital Vol. 112: Sabrina's Monster Manual
_Sabrina the Teenage Witch has a lot of strange friends! If it's spooky and scary, it's probably been a guest in the Spellman house! Monsters, ghosts, vampires½they're all real, and a lot friendlier than you think. This special digital exclusive book collects over 150 pages of Sabrina's most monstrous friends. For her, Halloween is every day!
