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IGF1R Expression by Adult Oligodendrocytes is Not Required in the Steady-state But Supports Neuroinflammation
Abstract: In the central nervous system (CNS), insulin-like growth factor 1 (IGF-1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti-apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work also suggests that IGF-1 protects ODCs from cell death and enhances remyelination in models of toxin-induced and autoimmune demyelination. However, since evidence remains controversial, the therapeutic potential of IGF-1 in demyelinating CNS conditions is unclear. To finally shed light on the function of IGF1-signaling for ODCs, we deleted insulin-like growth factor 1 receptor (IGF1R) specifically in mature ODCs of the mouse. We found tha...
Handbook of Embodied Cognition and Sport Psychology
The first systematic collaboration between cognitive scientists and sports psychologists considers the mind–body relationship from the perspective of athletic skill and sports practice. This landmark work is the first systematic collaboration between cognitive scientists and sports psychologists that considers the mind–body relationship from the perspective of athletic skill and sports practice. With twenty-six chapters by leading researchers, the book connects and integrates findings from fields that range from philosophy of mind to sociology of sports. The chapters show not only that sports can tell scientists how the human mind works but also that the scientific study of the human mind can help athletes succeed. Sports psychology research has always focused on the themes, notions, and models of embodied cognition; embodied cognition, in turn, has found striking confirmation of its theoretical claims in the psychological accounts of sports performance and athletic skill.
Volition and Personality
This is an impressive book, which presents a profoundly new approach to analyzing human behavior. The fundamental concept is to focus on how people link motivation with action and why they do or do not stick with their original intentions. The fascinating studies reported here attempt to separate people into two groups: (1) State-oriented individuals who focus under stress on past, present, or future states, rather than on options available for action; versus (2) Action-oriented individuals who focus under stress on action alternatives. This book will be of great interest to both behavioral and cognitive psychologists, psychophysiologists, and specialists in sport as well as aviation psychology.
Globalization 2.0
. . . Eat not up your property among yourselves unjustly except it be a trade amongst you, by mutual consent . . . and help you one another in righteousness and piety. . . (Al-Hadid 4:29; Al-Ma’idah 5:2) There cannot be any doubt that the current ?nancial crisis, which began in the US, has gone global. This realization has fuelled the ?re of debate over globalization. Today’s globalization is no longer the globalization that Theodore Levitt, a former professor at the Harvard Business School, described in 1983 in his world famous article ‘‘The Globalization of Markets. ’’ Although, in old days, Levitt and his successors had not seen globalization as an utopian state free of proble...
Rembrandts Strich
The Dresden collection's singular group of Rembrandt works - about 20 drawings attributed to the master today and the nearly complete oeuvre of etchings- will provide the basis for this remarkable publication. It will have a particular focus on Rembrandt's narrative compositions, printed self-portraits, studies of his wife Saskia, and will include works from all periods of his oeuvre plus prints and drawings by artists from his workshop and followers. The list of artists who understood Rembrandt as a dynamic authority and source of inspiration is long, reaching from his immediate followers to masters of the 18th century, from Giovanni Benedetto Castiglione to Jonathan Richardson to the kindr...
2012
Particularly in the humanities and social sciences, festschrifts are a popular forum for discussion. The IJBF provides quick and easy general access to these important resources for scholars and students. The festschrifts are located in state and regional libraries and their bibliographic details are recorded. Since 1983, more than 659,000 articles from more than 30,500 festschrifts, published between 1977 and 2011, have been catalogued.
