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Epigenetic Modifications Precede Molecular Alterations and Drive Human Hepatocarcinogenesis
Abstract: Development of primary liver cancer is a multi-stage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChips and RNA sequencing analyses for genome-wide methylome and transcriptome profiling of cirrhotic liver (n=7), low- (n=4) and high-grade (n=9) dysplastic lesions, early (n=5) and progressed (n=3) hepatocellular carcinomas (HCC) synchronously detected in eight HCC patients with chronic hepatitis B infection. Integrative analyses of epigenetically driven molecular changes were identified and validated in two independent cohorts comprising 887 HCC. Mitochondrial DNA sequencing was further...
Gen6cidi8
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Silver Masters of Mexico
This magnificent presentation introduces master designers and silversmiths with particular focus on one of the principal designers, Hctor Aguilar, and the personnel at this workshop. Valentin Vidaurreta, Los Castillo, William Spratling, Antonio Pineda, Hubert Harmon, Enrique Ledesma, and many more craftsmen are included. Beautifully illustrated with hundreds of examples of their artistry, including a guide to current market values.
Annual Report
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Encyclopedia of Signaling Molecules
The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
The Devil's Book of Culture
Since the 1950s, the Sierra Mazateca of Oaxaca, Mexico, has drawn a strange assortment of visitors and pilgrims—schoolteachers and government workers, North American and European spelunkers exploring the region's vast cave system, and counterculturalists from hippies (John Lennon and other celebrities supposedly among them) to New Age seekers, all chasing a firsthand experience of transcendence and otherness through the ingestion of psychedelic mushrooms "in context" with a Mazatec shaman. Over time, this steady incursion of the outside world has significantly influenced the Mazatec sense of identity, giving rise to an ongoing discourse about what it means to be "us" and "them." In this hi...
Social Inequities and Contemporary Struggles for Collective Health in Latin America
This book explores the legacy of the Latin American Social Medicine and Collective Health (LASM-CH) movements and other key approaches--including human rights activism and popular opposition to neoliberal governance--that have each distinguished the struggle for collective health in Latin America during the 20th and now into the 21st century. At a time when global health has been pushed to adopt increasingly conservative agendas in the wake of global financial crisis and amidst the rise of radical-right populist politics, attention to the legacies of Latin America's epistemological innovations and social movement action are especially warranted. This collection addresses three cross-cutting ...
