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Antiepileptic Drugs
The thoroughly revised, updated Fifth Edition of this classic is the m ost comprehensive, current, and authoritative reference on all anticon vulsants available today. This edition features detailed profiles of n ewer drugs--including levetiracetam, oxcarbazepine, tiagabine, topiram ate, and zonisamide--and new chapters on use of antiepileptic drugs in children and during pregnancy. Drugs are covered in alphabetical ord er and in an easy-to-follow format: mechanisms of action; chemistry, b iotransformation, and pharmacokinetics; interactions; clinical efficac y and use; and adverse effects. Coverage of clinical use includes none pileptic and psychiatric disorders where appropriate. This edition has been trimmed to manageable size by shortening chapters on older, less frequently used drugs.
Theory of the Firm
This book has an objective and a focus. It provides the reader with: • an in-depth acquaintance with the theory of the firm developed by Erich Gutenberg • an insight into a coherent body of current German research in the theory of the firm. The book is divided into two parts. The first part lays the foundations. It presents Gutenberg's theory of the firm to the English speaking reader. Considering the great importance that Erich Gutenberg has had in Germany and taking into consideration the impact that the translations of his path-breaking three volumes "Principles of Management" have had in France, the Spanish speaking countries, and in Japan, it was felt that it was necessary, on the o...
Infinity
This interdisciplinary study of infinity explores the concept through the prism of mathematics and then offers more expansive investigations in areas beyond mathematical boundaries to reflect the broader, deeper implications of infinity for human intellectual thought. More than a dozen world-renowned researchers in the fields of mathematics, physics, cosmology, philosophy and theology offer a rich intellectual exchange among various current viewpoints, rather than displaying a static picture of accepted views on infinity. The book starts with a historical examination of the transformation of infinity from a philosophical and theological study to one dominated by mathematics. It then offers technical discussions on the understanding of mathematical infinity. Following this, the book considers the perspectives of physics and cosmology: can infinity be found in the real universe? Finally, the book returns to questions of philosophical and theological aspects of infinity.
Progress in the Chemistry of Organic Natural Products 115
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
General Relativity
General Relativity provides an unusually broad survey of the current state of this field. Chapters on mathematical relativity cover many topics, including initial value problems, a new approach to the partial differential equations of physics, and work on exact solutions. The chapters on relativistic cosmology and black holes explore cosmology. Other chapters deal with gravitational waves, experimental relativity, quantum gravity, and aspects of computing in relativity. The book will be useful both to postgraduates and to established workers in the field.
Epilepsy in the Tropics
This book focuses on epidemiology, diagnosis, symptomatology, clinical biology, treatment, economics, and health care. It will be a guidebook for professionals in tropical countries engaged in the care of people with epilepsy.
Knowledge-Based Simulation
Knowledge-Based Simulation: Methodology and Application represents a recent compilation of research material that reviews fundamental concepts of simulation methodology and knowledge-based simulation applications. Knowledge-based simulation represents a new and exciting bridge area linking the fields of computer simulation and artificial intelligence. This book will appeal to both theorists and practitioners who require simulation to solve complex problems. A primary attraction of the book is its emphasis on both methodology and applications. In this way, the reader can explore new methods for encoding knowledge-inten- sive information into a simulation model, and new applications that utilize these methods.
Responsible Trading in Raw Materials
As environmental social governance (ESG) increasingly shapes the academic discourse in the European Union, Solveig Gasche provides a conceptual analysis of responsible trading in raw materials. Because the governance concept of responsible trading considers human rights and environmental standards, she defines the decisive determinants of trade in raw materials by considering the main historic, economic and regulative approaches. Illustrating and analysing the international and the German approach to implementing good guidance, strategies and governance, she further deals with the issues of conflict minerals and compliance, supply chain due diligence, corporate social responsibility, and business ethics. Corporate liability is given particular emphasis, taking into account options of contract design, transparency, and reporting as well as aspects of due diligence.
