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In Silico Methods for Drug Design and Discovery
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Tissue-Specific Cell Signaling
Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Southern Europe in the Mediterranean Context
Since the process of Southern Europe's integration in the European Union, the Mediterranean region has seen a more considerable gap between central and northern European countries and its Southern European counterpart. Thus, in a European context of social cohesion, it becomes necessary to better understand Southern Europe, without escaping to the common perception of the complexity of Mediterranean culture. As a significant player throughout history, Southern Europe consistently established a platform of diversity and freedom, bringing peace between different historic-cultural traditions. Moreover, the southern frontier of Europe to Africa and Asia has become a crucial determinant in the current times of change.
From Specification to Embedded Systems Application
As almost no other technology, embedded systems is an essential element of many innovations in automotive engineering. New functions and improvements of already existing functions, as well as the compliance with traffic regulations and customer requirements, have only become possible by the increasing use of electronic systems, especially in the fields of driving, safety, reliability, and functionality. Along with the functionalities that increase in number and have to cooperate, the complexity of the entire system will increase. Synergy effects resulting from distributed application functionalities via several electronic control devies, exchanging information through the network brings abou...
Handbook on Teaching and Learning for Sustainable Development
Exploring the important role of education in both pursuing and implementing sustainable development, this timely Handbook highlights how teaching methods at schools and universities can impact the future. It looks at ways not only to inform students about matters related to sustainable development, but also to empower them to adopt behaviours and actions that lead to more sustainable lifestyles.
Accelerating Modernization with Agile Integration
The organization pursuing digital transformation must embrace new ways to use and deploy integration technologies, so they can move quickly in a manner appropriate to the goals of multicloud, decentralization, and microservices. The integration layer must transform to allow organizations to move boldly in building new customer experiences, rather than forcing models for architecture and development that pull away from maximizing the organization's productivity. Many organizations have started embracing agile application techniques, such as microservice architecture, and are now seeing the benefits of that shift. This approach complements and accelerates an enterprise's API strategy. Business...
Perspectives and Trends in Education and Technology
This book presents high-quality, peer-reviewed papers from the International Conference in Information Technology & Education (ICITED 2022), to be held at the ESPM – Higher School of Advertising and Marketing, Rio de Janeiro, Brazil, between July 14 – 16, 2022. This book covers a specific field of knowledge. This intends to cover not only two fields of knowledge – Education and Technology – but also the interaction among them and the impact/result in the job market and organizations. It covers the research and pedagogic component of Education and Information Technologies and also the connection with Society, addressing the three pillars of higher education. This book addresses impact of pandemic on education and use of technology in education. Finally, it also encourages companies to present their professional cases which will be discussed. These can constitute real examples of how companies are overcoming their challenges with the uncertainty of the market.
SOCCER WORLD 2012/2013
Soccer World è l'unico annuario statistico sul calcio internazionale prodotto interamente in Italia. Forte di una quantità innumerevole di statistiche il volume permette di conoscere informazioni spesso non comuni ad altre pubblicazioni del settore come per esempio i dati societari di tutti i club presenti, gli organici minuziosamente aggiornati di oltre 500 squadre e l'analisi tattica di ognuna di esse con le disposizioni in campo dei giocatori. Inoltre l'elenco dei più importanti movimenti del calciomercato estivo uniti ad un resoconto dettagliato della stagione precedente con il palmarès di ogni squadra rendono ogni edizione una piccola pietra miliare nel suo genere. Utile sia per l'esperto del settore che per il semplice appassionato. Imperdibile!
