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Approach Based on Phenotype and EndotypeAsthma Diagnosis and Management
Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease "phenotype" and "endotype," which allowed precision medicine therapies, including new asthma biologics. This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes.
Asthma Diagnosis and Management - Approach Based on Phenotype and Endotype
Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease ""phenotype"" and ""endotype,"" which allowed precision medicine therapies, including new asthma biologics. This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes.
Severe Asthma
This book presents state of the art knowledge on severe asthma with the aim of providing readers with a clear understanding of, first, the heterogeneity of the condition and of patients’ symptom profiles and responses to therapy and, second, the future implications of this heterogeneity for individualized patient care. After an opening section that offers an overview of severe asthma, including its clinical significance, the pathogenesis, available diagnostic approaches, and treatment options are described in detail. The sections on diagnosis and treatment cover the role of biomarkers, the use of radiologic diagnostic modalities, and both pharmacologic and non-pharmacologic therapies, including emerging options that will address hitherto unmet needs of patients. The outcomes of cutting-edge preclinical and clinical research are carefully documented and numerous useful tips provided on patient management. The inclusion of many informative schematic figures will assist readers in grasping the contents easily. The book will be of high value for medical students, researchers, general physicians, specialists, and paramedical staff.
Home Reading Service
In this poignant novel, a man guilty of a minor offense finds purpose unexpectedly by way of his punishment—reading to others. After an accident—or “the misfortune,” as his cancer-ridden father’s caretaker, Celeste, calls it—Eduardo is sentenced to a year of community service reading to the elderly and disabled. Stripped of his driver’s license and feeling impotent as he nears thirty-five, he leads a dull, lonely life, chatting occasionally with the waitresses of a local restaurant or walking the streets of Cuernavaca. Once a quiet town known for its lush gardens and swimming pools, the “City of Eternal Spring” is now plagued by robberies, kidnappings, and the other myriad ...
The KMT Returns to Power
In this book the author examines how the Nationalist Party (Kuomintang or KMT) returned to govern Taiwan after ruling for more than half a century but losing power in 2000 when the opposition Democratic Progressive Party’s (DPP) Chen Shui-bian won the presidency and was reelected in 2004. Out of power and playing the role of opposition party the KMT won legislative and executive elections in 2008. It subsequently won mayoral elections in 2010 and elections again to the legislative and executive branches of government in 2012. The KMT returned to power by resolving internal differences between older and younger factions in the party, maintaining an alliance with friendly parties and prevent...
High As the Waters Rise
This "gorgeously written" National Book Award finalist is a dazzling, heart-rending story of an oil rig worker whose closest friend goes missing, plunging him into isolation and forcing him to confront his past (NPR, One of the Best Books of the Year). One night aboard an oil drilling platform in the Atlantic, Waclaw returns to his cabin to find that his bunkmate and companion, Mátyás, has gone missing. A search of the rig confirms his fear that Mátyás has fallen into the sea. Grief-stricken, he embarks on an epic emotional and physical journey that takes him to Morocco, to Budapest and Mátyás's hometown in Hungary, to Malta, Italy, and finally to the mining town of his childhood in Ge...
To the Warm Horizon
A group of Koreans are making their way across a disease-ravaged landscape—but to what end? To the Warm Horizon shows how in a post-apocalyptic world, humans will still seek purpose, kinship, and even intimacy. Focusing on two young women, Jina and Dori, who find love against all odds, Choi Jin-young creates a dystopia where people are trying to find direction after having their worlds turned upside down. Lucidly translated from the Korean by Soje, this thoughtful yet gripping novel takes the reader on a journey through how people adjust, or fail to adjust, to catastrophe.
