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Recent Advances in the Immunology of Helminth Infection – Protection, Pathogenesis and Panaceas
Dr. Paul Giacomin is a co-founder of Paragen Bio. Dr. Siracusa is the founder and president of Nemagen Discoveries. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Le recrutement des basophiles induit par la prostaglandine D2 et dépendant de CXCR4 contribue à la pathologie lupique
Le lupus systémique érythémateux (SLE) est maladie autoimmune multifactorielle caractérisée par la présence d'anticorps autoréactifs pathogènes. Les basophiles sont connus pour pouvoir augmenter la production de ces anticorps autoréactifs au cours du SLE en s'accumulant dans les organes lymphoïdes secondaires (SLOs) où ils supportent l'activation et la prolifération des plasmocytes. Les mécanismes de recrutement des basophiles vers les SLOs ne sont pas clairement établis et pourraient être des cibles thérapeutiques dans le SLE. Nous démontrons qu'une basopénie périphérique et une forte proportion de basophiles HLA-DR+ sont spécifiques de la néphrite lupique et associés...
The Role of Toll-like Receptors and their Related Signaling Pathways in Viral Infection and Inflammation
Toll-like receptors (TLRs) represent a powerful system for recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. TLRs are mainly expressed on immune cells, but can also be present on other cell populations. Typical PAMPs include bacterial cell wall components, viral pathogens, or pathogenic nucleic acids, including viral RNA and DNA. Activation of TLRs leads to the production of proinflammatory cytokines and type I interferons which are important for induction of the host immune response against bacterial and viral infections. However, dysregulation and overstimulation can be detrimental leading to hyper-inflammation, sepsis, and loss of tissue integrity. Furthermore, TLRs are involved in the pathogenesis of acute viral infections, including COVID-19. Consequently, TLRs are promising targets for pharmacological intervention and treatment.
OPLL
This publication brings together information on all aspects of OPLL - epidemiology, etiology, diagnosis, and treatment. It contains contributions by Japanese researchers and surgeons, including members of the Ministry of Health and Welfare Investigation Committee, and by American surgeons with expertise in the field. Until now, little has been published on the subject in English. This collection of reports is amply augmented with illustrations.
Casebook of Neuropsychiatry
Casebook of Neuropsychiatry is comprised of 38 clinical cases based on real patient interactions that straddle the domains of neurology and psychiatry. The book is designed to supplement comprehensive texts by providing real-world accounts of patient presentations that clinicians are likely to encounter.
Flow Cytometry and Cell Sorting
The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS
