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Regulation and targeting of enzymes mediating Parkinson’s disease pathogenesis: focus on Parkinson’s disease Kinases, GTPases and ATPases
Understanding the molecular pathogenesis of Parkinson’s disease (PD) is a priority in biomedical research and a pre-requisite to improve early disease diagnosis and ultimately to developing disease-modifying strategies. In the past decade and a half, geneticists have identified several genes that are involved in the molecular pathogenesis of PD. They not only identified gene variants segregating with familial forms of PD but also genetic risk factors of sporadic PD via genome-wide association studies (GWAS). Understanding how PD genes and their gene products function holds the promise of unraveling key PD pathogenic processes. Therefore the precise cellular role of PD proteins is currently...
Disease-Modifying Targets in Neurodegenerative Disorders
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. - Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress - Summarizes how patients are treated today, providing a glance at future disease management - Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists - Written and peer reviewed by outstanding scientists in their respective fields
Disease-Modifying Targets in Neurodegenerative Disorders
Disease-Modifying Therapies and Targets in Neurodegenerative Disorders examines specific neurodegenerative disorders chapter-by-chapter, each written by experts in the respective fields. Each chapter contains a summary of the disease management field as it stands today and subsequently elaborates on the molecular mechanisms and new promising targets for disease-modifying therapies. This includes targets which are generally believed to hold great promise with a view to therapy, targets in the first stages of preclinical research, as well as therapeutic strategies in a more advanced stage. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, prov...
Leucine-Rich Repeat Kinase 2 (LRRK2)
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Kinase Drug Discovery
Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development. Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and identifies a number of hot topics and key areas for kinase drug discovery over the coming years. It includes contributions from highly respected authors with a combined experie...
The Omega
None
Startle Modification
A comprehensive volume devoted to startle modification.
The Dark Side of Behaviour at Work
Corporations of every size have experience of employees who are guilty of lying, stealing, sabotage, hacking, destruction of files and data, and more than a few corporations have been, and continue to be, devastated by the activities of whistleblowers. Profits, secrets and staff morale are all threatened. This book provides a background to the psychology of deviance and offers practical advice about identifying the causes of and prescriptions for reversing disloyalty.
Fish Osmoregulation
Fish lives in environments with a wide variety of chemical characteristics (fresh, brackish and seawater, acidic, alkaline, soft and hard waters). From an osmoregulatory point of view, fish have developed several mechanisms to live in these different environments. Fish osmoregulation has always attracted considerable attention and in the last years several studies have increased our knowledge of this physiological process. In this book several specialists have analyzed and reviewed the new data published regarding fish osmoregulation. The chapters present an integrative synthesis of the different aspects of this field focusing on osmoregulation in specific environments or situations, function of osmoregulatory organs, general mechanisms and endocrine control. In addition, interactions of osmoregulatory mechanisms with the immune system, diet and metabolism were also reviewed. New emerging techniques to study osmoregulation has also been analysed.
