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The Creation of Psychopharmacology
David Healy follows his widely praised study, The Antidepressant Era, with an even more ambitious and dramatic story: the discovery and development of antipsychotic medication. Healy argues that the discovery of chlorpromazine (more generally known as Thorazine) is as significant in the history of medicine as the discovery of penicillin, reminding readers of the worldwide prevalence of insanity within living memory. But Healy tells not of the triumph of science but of a stream of fruitful accidents, of technological discovery leading neuroscientific research, of fierce professional competition and the backlash of the antipsychiatry movement of the 1960s. A chemical treatment was developed fo...
A Decade of Hubble Space Telescope Science
The Hubble Space Telescope has made some of the most dramatic discoveries in the history of astronomy. From its vantage point 600km above the Earth, Hubble is able to capture images and spectra that would be difficult or impossible to obtain from the ground. This volume represents some of the most important scientific achievements of the Hubble Space Telescope in its first decade of operation. Written by world experts, this is an indispensable collection of review articles for researchers and graduate students.
Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques
Volume 46 of this well-established and acclaimed book series contains seven comprehensive reviews by internationally recognized experts. They will provide the reader with up-to-date information. Contents: N.K. Hollenberg and S.W. Graves: Endogenous sodium pump inhibition: Current Status • R.B. McCall: Neurotransmitters involved in the central regulation of the cardivascular system • W.T. Jackson and J.H. Fleisch: Development of novel anti- inflammatory agents: A pharmacologic perspective on leukotrienes and their receptors • M. Margaglione, E. Grandone, F.P. Mancini and G. Di Minno: Drugs affecting plasma fibrinogen levels. Implications for new antithrombotic strategies • N. Seiler, A. Hardy and J.P. Moulinoux: Aminoglycosides and polyamines: Targets and effects in the mammalian organism of two important groups of natural aliphatic polycations • J. Claghorn and M.D. Lesem: Recent developments in antidepressant agents • E.J. Lien, A. Das and L.L. Lien: Immunopharmacological and biochemical bases of Chinese herbal medicine • Index Vol. 46 • Index of titles Vols. 1-46 • Author and paper index Vols. 1-46.
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
Volume 24 includes six contributions, the author and paper index of volumes 1-24 and the key-word index. Since volume 23 included an index for volumes 16-23 the reader has the possibility to use these monographs as an encyclopedia and is in the position to find references to almost all fields of drug research. The editor hopes that the articles of the present volume will prove interesting and useful to many scientists and would be grateful to receive suggestions and opinions from readers, as in the past case over the 20 years in which this series of monographs has existed. In this respect, thanks are due to all colleagues who have provided helpful criticism of past volumes, thereby helping the editor in his work. Dr. A. Naf again has assisted the editor and has carefully reviewed all manuscripts, formulae and references, and has corrected the proofs. Thanks are due to him for this immense work. At the same time, the editor would like to thank the publishers and printers, Verlag Birkhliu ser, in particular Messrs. Th. Birkhliuser and C. Einsele, for the excellent cooperation and the work they have accomplished.
Progress in Drug Research 56
Founded in 1959 by its current Editor, the series has moved from its initial focus on medicinal chemistry to a much wider scope. Today it encompasses all fields concerned with the development of new therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drug research. Invited authors present their biological, chemical, biochemical, physiological, immunological, pharmaceutical, toxicological, pharmacological and clinical expertise in carefully written reviews and provide the newcomer and the specialist alike with an up-to-date comprehensive list of prime references. Each volume of Progress in Drug Research contains fully cross-referencing indices which link the books together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
Bayesian Population Analysis Using WinBUGS
Bayesian statistics has exploded into biology and its sub-disciplines, such as ecology, over the past decade. The free software program WinBUGS, and its open-source sister OpenBugs, is currently the only flexible and general-purpose program available with which the average ecologist can conduct standard and non-standard Bayesian statistics. Comprehensive and richly commented examples illustrate a wide range of models that are most relevant to the research of a modern population ecologist All WinBUGS/OpenBUGS analyses are completely integrated in software R Includes complete documentation of all R and WinBUGS code required to conduct analyses and shows all the necessary steps from having the data in a text file out of Excel to interpreting and processing the output from WinBUGS in R
Astronomy from Wide-Field Imaging
H.T. MacGilLIVRAY Royal Observatory Blackford Hill Edinburgh EH9 3HJ Scotland U.K. lAU Symposium No. 161 on 'Astronomy from Wide-Field Imaging', held in Potsdam, Germany, during 23-27th August 1993, was the first conference organised by the recently-formed Working Group of lAU Commission 9 on 'Wide-Field Imaging'. This Working Group was instigated during the XXIst meeting of the General Assembly of the International Astronomical Union in Buenos Aires in 1991, and represented a merging of the former formal lAU Working Group on 'Astronomical Photography' and the informal 'Digitised Optical Sky Surveys' Working Group. Dr. Richard West was 'invited' to be Chairperson, and hence was given the dau...
Progress in Drug Research
S. Ren and E.J. Lien: CaCo-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.- J.C.G. Halford and J.E. Blundell: Pharmacology of appetite suppression.- B. Olivier, W. Soudijn and I. van Wijngaarden: Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors.- D. Poyner, H. Cox, M. Bushfield, J.M. Treherne and M.K. Demetrikopoulos: Neuropeptides in drug research.- M. Kumari and M.K. Ticku: Regulation of NMDA receptors by ethanol.- H. Horikoshi, T. Hashimoto and T. Fujiwara: Troglitazone and emerging glitazones: new avenues for potential therapeutic benefits beyond glycemic control.- Rosamund C. Smith and Simon J. Rhodes: Applications of developmental biology to medicine and animal agriculture.
Progress in Drug Research
From the contents: · C. Brater and M. D. Murray: The effects of NSAIDs on the kidney · G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs · M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms · S.P. Gupta: Studies on cardiovascular drugs · G. Polak: Antifungal chemotherapy: An everlasting battle · O. Valdenaire: New insights into the bioamine receptor family.
Creating Modern Neuroscience: The Revolutionary 1950s
For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the ...
