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Tissue-Resident Macrophages
This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and monocyte-derived macrophages. The contents aim to describe the current knowledge about macrophage development and function which forces the scientific field to move beyond the previously described M1/M2 macrophage paradigm to be able to dissect macrophage functions within their specific niches during health and disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Tissue-Resident Macrophages: Methods and Protocols provides scientists entering the macrophage field with information and tools that allow them to dive into the state-of-the-art methodology used in this vital field.
Marketing Countries, Places, and Place-Associated Brands
This book integrates new thinking on the image, marketing, and branding of places at all levels, from town squares to cities and countries, and of the products and peoples associated with them, thereby bridging the 'country' and 'place' silos in place-related research and practice. Insightful contributions from top scholars reflect fresh theorizing and provide a critical appraisal of conventional wisdom by juxtaposing intriguing contexts, questioning commonplace practices, and challenging methodologies and theoretical assumptions. Chapters explore interdependencies among residents, visitors, brand managers, and consumers; image effects of place and social identity, cross-border acquisitions,...
Neurobiology of Chemical Communication
Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediat...
Muscle Function and Homeostasis Require Cytokine Inhibition of AKT Activity in Drosophila
Abstract: Unpaired ligands are secreted signals that act via a GP130-like receptor, domeless, to activate JAK/STAT signalling in Drosophila. Like many mammalian cytokines, unpaireds can be activated by infection and other stresses and can promote insulin resistance in target tissues. However, the importance of this effect in non-inflammatory physiology is unknown. Here, we identify a requirement for unpaired-JAK signalling as a metabolic regulator in healthy adult Drosophila muscle. Adult muscles show basal JAK-STAT signalling activity in the absence of any immune challenge. Plasmatocytes (Drosophila macrophages) are an important source of this tonic signal. Loss of the dome receptor on adult muscles significantly reduces lifespan and causes local and systemic metabolic pathology. These pathologies result from hyperactivation of AKT and consequent deregulation of metabolism. Thus, we identify a cytokine signal that must be received in muscle to control AKT activity and metabolic homeostasis
cis-trans Isomerization in Biochemistry
Collating the knowledge from over 20,000 publications in chemistry, biology and nanotechnology, this handbook is the first to comprehensively present the state of the art in one ready reference. A team of international authors connects the various disciplines involved, covering cis-trans isomerization of double bonds and pseudo-double bonds, as well as other cis-trans isomerizations. For biochemists, organic chemists, physicochemists, photochemists, polymer and medicinal chemists.
Housing and Human Settlements in a World of Change
The challenge of housing is increasingly recognised in international policy discussions in connection to the processes of migration, climate change, and economic globalisation. This book addresses the challenges of housing and emerging solutions along the lines of three major dynamics: migration, climate change, and neo-liberalism. It explores the outcomes of neo-liberal »enabling« ideas, responses to extreme climate events with different housing approaches, and how the dynamics of migration reshape the urban housing provision in a changing world. The aim is to contextualise the theoretical discourses by reflecting on the case study context of the eleven papers published in this book. With forewords by Raquel Rolnik (University Sao Paulo) and Mohammed El Sioufi (UN-Habitat).
Medicinal Chemistry for Practitioners
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
