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Never-resting microglia: physiological roles in the healthy brain and pathological implications
Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formati...
Tissue-Resident Macrophages
This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and monocyte-derived macrophages. The contents aim to describe the current knowledge about macrophage development and function which forces the scientific field to move beyond the previously described M1/M2 macrophage paradigm to be able to dissect macrophage functions within their specific niches during health and disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Tissue-Resident Macrophages: Methods and Protocols provides scientists entering the macrophage field with information and tools that allow them to dive into the state-of-the-art methodology used in this vital field.
Neuroglia
Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anat...
Molecular Basis of Multiple Sclerosis
Despite major efforts by the scientific community over the years, our understanding of the pathogenesis or the mechanisms of injury of multiple sclerosis is still limited. Consequently, the current strategies for treatment and management of patients are limited in their efficacy. The mechanisms of tissue protection and repair are probably even less understood. One reason for these limitations is the enormous complexity of the disease and every facet of its pathogenesis, the mechanisms of tissue injury, the diagnostic procedures and finally the efficacy of treatments and their side effects. The aim of this book is to review the most recent advances made in this highly complex field.
Neuroimmune System
The book explores the intricate connections between the nervous and immune systems in the context of neurodegenerative disorders, offering a comprehensive overview of the bidirectional communication between these systems and their implications for disease progression and therapeutic interventions. The book aims to understand the recent developments in the field of neuroimmune communication. Key Features: In-depth analysis of immunological biomarkers and therapeutic targets for neurodegenerative disorders. Exploration of the role of glial cells in neuroimmune interactions and their dual nature in disease pathology. Examination of short- and long-range interactions between the central nervous ...
빼기의 기술
★★★ SERICEO 비즈니스 북클럽 선정 도서 ★★★ 애덤 그랜트, 캐럴 드웩, 배리 슈워츠 강력 추천 ★★★ “빼기는 실용적인 도구이자 위대한 기술이다” _댄 히스, 《스틱!》 저자 ★★★ 해외 유수 매체가 선정한 최고의 책 지금껏 당신이 성과를 내기 위해 해왔던 ‘더하기’ 방식은 틀렸다! 우리는 ‘할 일’을 쌓아가지만 ‘하지 말아야 할 일’은 생각조차 하지 않는다. 기업은 인센티브로 직원들을 독려하지만 생산성을 가로막는 장애물은 제거하지 않는다. 세상은 새로운 발상을 계속해서 모으지만 낡은 관습은 제거하지 ...
Minus
Cercetările lui Leidy Klotz au condus la un adevăr simplu: indiferent dacă este vorba despre construirea unor jucării cu piese de lego, planurile de urbanizare, sendvișuri sau strategiile de afaceri, mintea e tentată să adauge, în loc să scadă. Adunăm instinctiv lucruri care nu ne trebuie neapărat. Le oferim stimulente celor cu performanțe remarcabile, dar nu ne gândim să înlăturăm obstacolele din calea lor. Ne însușim idei noi, care să ne facă lumea mai bună, dar nu renunțăm mai întâi la cele învechite și dăunătoare. În școli și facultăți acumulăm cunoștințe pe care le vom uita imediat după absolvire.
Galen on Anatomical Procedures
This edition of Galen's Anatomical Procedures (c. AD 200) offers parts of book 9 and books 10-15.
Sinusoidal Cells in Liver Diseases
Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarke...
