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ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier
Abstract: Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion maturation of podocyte protrusions and thereby regulates formation, maintenance, and capacity to adapt to mechanical requirements of the filtration barrier. We find that N-WASP-Arp2/3 define the development of complex arborized podocyte protrusions in vitro and in vivo. Loss of dendritic actin networks results in a pronounced activation of the actomyosin cytoskeleton and the generation of over-maturated but less efficient adhesion, leading to detachment of podocytes. Our data provide a model to explain podocyte protrusion morphology and their mechanical stability based on a tripartite relationship between actin polymerization, contractility, and adhesion
Florian Geyer
None
Heparin-Induced Thrombocytopenia
Taking stock of advances in clinical recognition, laboratory testing, and pharmacologic therapy as well as basic aspects of pathogenesis, the Third Edition of Heparin-Induced Thrombocytopenia reinforces its standing as the leading guide to accurate diagnosis and effective management of this complex condition. Featuring added chapters on bivalirudin
Groundwater Ecology and Evolution
Groundwater Ecology and Evolution, Second Edition is designed to meet a multitude of audience needs. The state of the art in the discipline is provided by the articulation of six sections. The first three sections successively carry the reader into the basic attributes of groundwater ecosystems (section 1), the drivers and patterns of biodiversity (section 2), and the roles of organisms in groundwater ecosystems (section 3). The next two sections are devoted to evolutionary processes driving the acquisition of subterranean biological traits (section 4) and the way these traits are differently expressed among groundwater organisms (section 5). Finally, section 6 shows how knowledge acquired a...
Expanded Hemodialysis
Despite constant significant advances, cardiovascular as well as more general outcomes of hemodialysis treatment remain unsatisfactory. The introduction of innovative 'high retention onset' membranes has led to the development of a new treatment modality called 'expanded hemodialysis' (HDx), which is the focus of this book. This new therapy is likely to benefit end-stage kidney disease patients, thanks to enhanced removal of molecules retained by current dialysis techniques. HDx is simple to set up and application does not require special hardware or specific nursing skills. This book contains emerging evidence and fascinating new hypotheses on HDx. It is highly recommended for all physicians and healthcare professionals who are caring for dialysis patients and are seeking innovation and improved care solutions. It will also be of considerable interest to students and fellows.
Habsburg Lemberg
When Austria annexed Galicia during the first partition of Poland in 1772, the province's capital, Lemberg, was a decaying Baroque town. By the outbreak of the First World War in 1914, Lemberg had become a booming city with a modern urban and, at the same time, distinctly Habsburg flavor. In the process of the "long" nineteenth century, both Lemberg's appearance and the use of public space changed remarkably. The city center was transformed into a showcase of modernity and a site of conflicting symbolic representations, while other areas were left decrepit, overcrowded, and neglected. Habsburg Lemberg: Architecture, Public Space, and Politics in the Galician Capital, 1772–1914 reveals that behind a variety of national and positivist historical narratives of Lemberg and of its architecture, there always existed a city that was labeled cosmopolitan yet provincial; and a Vienna, but still of the East. Buildings, streets, parks, and monuments became part and parcel of a complex set of culturally driven politics.
Wer bist du, Florian?
Im Sonnenwinkel ist eine Familienroman-Serie. Schauplätze sind der am Sternsee gelegene Sonnenwinkel und die Felsenburg, eine beachtliche Ruine von geschichtlicher Bedeutung. Mit Michaela Dornberg übernimmt eine sehr erfolgreiche Serienautorin, die Fortsetzung der beliebten Familienserie "Im Sonnenwinkel". Michaela Dornberg ist mit ganzem Herzen in die bezaubernde Welt des Sonnenwinkels eingedrungen. Sie kennt den idyllischen Flecken Erlenried und die sympathische Familie Auerbach mit dem Nesthäkchen Bambi. Roberta konnte sich ihre Aufregung nicht erklären, die sich noch verstärkte, als der Fremde sich betont langsam zu ihr herumdrehte. Sie schauten sich an. Für einen kurzen Augenblick...
Tumescent Technique
TUMESCENT TECHNIQUE is the definitive reference on all aspects of the tumescent technique of anesthesiology used in liposuction. Written by the inventor of the tumescent technique, this resource explains the pathophysiology, complications, pharmacology, and the different methods used to achieve great cosmetic results. Step-by-step instructions demonstrate how to perform this procedure on all areas of the body. Complications and postoperative care are also addressed. * Written by Dr. Klein, a leading expert in the field and the physician who invented and perfected the technique. * Provides step-by-step instructions for administering the local anesthesia with a practical, easy-to-follow approach. * Discusses tumescent liposuction techniques for each body region, addressing procedures, guidelines, and complications for each. * Covers complications and how to avoid them, preventing problems before they arise. * Provides detailed illustrations of techniques and before and after photographs to allow you to see expected results.
