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The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
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The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
When visitors travel to Pennsylvania Dutch Country, they are encouraged to consume the local culture by way of "regional specialties" such as cream-filled whoopie pies and deep-fried fritters of every variety. Yet many of the dishes and confections visitors have come to expect from the region did not emerge from Pennsylvania Dutch culture but from expectations fabricated by local-color novels or the tourist industry. At the same time, other less celebrated (and rather more delicious) dishes, such as sauerkraut and stuffed pork stomach, have been enjoyed in Pennsylvania Dutch homes across various localities and economic strata for decades. Celebrated food historian and cookbook writer William...
Abstract: Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion maturation of podocyte protrusions and thereby regulates formation, maintenance, and capacity to adapt to mechanical requirements of the filtration barrier. We find that N-WASP-Arp2/3 define the development of complex arborized podocyte protrusions in vitro and in vivo. Loss of dendritic actin networks results in a pronounced activation of the actomyosin cytoskeleton and the generation of over-maturated but less efficient adhesion, leading to detachment of podocytes. Our data provide a model to explain podocyte protrusion morphology and their mechanical stability based on a tripartite relationship between actin polymerization, contractility, and adhesion
This book presents a proposal for designing business process management (BPM) systems that comprise much more than just process modelling. Based on a purified Business Process Model and Notation (BPMN) variant, the authors present proposals for several important issues in BPM that have not been adequately considered in the BPMN 2.0 standard. It focusses on modality as well as actor and user interaction modelling and offers an enhanced communication concept. In order to render models executable, the semantics of the modelling language needs to be described rigorously enough to prevent deviating interpretations by different tools. For this reason, the semantics of the necessary concepts introd...
This book provides the most complete formal specification of the semantics of the Business Process Model and Notation 2.0 standard (BPMN) available to date, in a style that is easily understandable for a wide range of readers – not only for experts in formal methods, but e.g. also for developers of modeling tools, software architects, or graduate students specializing in business process management. BPMN – issued by the Object Management Group – is a widely used standard for business process modeling. However, major drawbacks of BPMN include its limited support for organizational modeling, its only implicit expression of modalities, and its lack of integrated user interaction and data ...