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Die Studie leistet einen empirisch-rekonstruktiven Beitrag zu einer machtkritisch ausgerichteten Fachdidaktik. Sie fokussiert den Deutschunterricht und die darin stattfindenden Interaktionen als diskursive Praxis, in der ein spezifisches Wissen in, über und angesichts von Sprache relevant gemacht wird. Für Subjektivierung ist jenes Wissen hochgradig wirkmächtig und bleibt den Akteur*innen im Prozess der schulischen Enkulturation doch größtenteils unbewusst. Darin liegt ein hohes Potential für die institutionelle (Re-)Produktion von Linguizismus.Vor diesem Hintergrund eröffnet die Studie einen Blick auf sprachbezogene Adressierungen, die in charakteristischer Weise vom Fach selbst ausgehen. Sie werden in (fach)didaktischen und pädagogischen Programmatiken breit kommuniziert und zeichnen sich bis auf die Ebene unterrichtlicher Praktiken ab. Um das Zusammenspiel von fachspezifischer Adressierung und Praktiken des ‚doing language‘ möglichst eng aufeinander beziehen und in rekonstruktionslogisch plausibilisierte Zusammenhänge bringen zu können, liegt der Arbeit ein wissenssoziologisch-diskursanalytischer Ansatz zugrunde.
B and T Cell Tumors documents the proceedings of the 1982 International Conference on ""B and T Cell Tumors: Biological and Clinical Aspects"" held in Squaw Valley, California. The meeting was one of the conferences of the 1982 UCLA Symposia on Molecular and Cellular Biology series. This book is organized into six parts encompassing 79 chapters. Considerable chapters tackle the origin and classification of tumors; normal clones of T and B cells; differentiation of T and B cell tumors; regulation of tumor growth and tumor therapy. Each topic is discussed based on the results obtained in human and animal models in the laboratory. Other chapters explore lymphoid neoplasms and the enormous progr...
This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.
Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.