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Epigenetic Therapy of Cancer
The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
Change Management in Action
An anthology of 60 interviews culled from "The Information Interview" feature of InfoManage: The International Management Newsletter for the Information Services Professional. The interviews were conducted with various leading professionals in business and public libraries. They are organized into broadly themed sections regarding conceptualizing change, organizing and planning management practices, entrepreneurial management, customer care, and quality management. Annotation copyrighted by Book News, Inc., Portland, OR
Extinction Studies
Extinction Studies focuses on the entangled ecological and social dimensions of extinction, exploring the ways in which extinction catastrophically interrupts life-giving processes of time, death, and generations. The volume opens up important philosophical questions about our place in, and obligations to, a more-than-human world. Drawing on fieldwork, philosophy, literature, history, and a range of other perspectives, each of the chapters in this book tells a unique extinction story that explores what extinction is, what it means, why it matters—and to whom.
Nitroreductase-mediated Release of Inhibitors of Lysine-specific Demethylase 1 (lsd1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells
Abstract: Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with the bacterial nitroreductase NfsB (NTR) that was expressed in the virally transfected AML cell line THP1-NTR+. The cellular activity of the NTR was proven with a new luminescent NTR probe. We synthesised a diverse set of nitroaromatic prodrugs that by design do not affect LSD1 and are reduced by the NTR to release an active LSD1 inhibitor. The emerging side products were differentially analysed using negative controls, thereby revealing cytotoxic effects. The 2-nitroimidazolyl prodrug of a potent LSD1 inhibitor emerged as one of the best prodrug candidates with a pronounced selectivity window between wild-type and transfected THP1 cells. Our prodrugs are selectively activated and release the LSD1 inhibitor locally, proving their suitability for future targeting approaches
Talking to the Spirits
A guide to direct communication with the spirits and the Gods • Offers practices for seekers and groups to learn to hear and respond to the spirits and the Gods as well as what to do (and not do) if you receive a message • Explains how to authenticate spiritual messages with divination • Discusses how to avoid theological conflicts when someone’s personal gnosis differs from that of their Pagan group For our ancestors the whole world was alive with spirits. The Gods bubbled forth from rivers and springs and whispered in the breezes that rustled through cities and farms. The ground underfoot, the stones, the fire that cooked the food and drove off the darkness, these all had spirits--...
Ar Or
Vols. 3- include Bulletin of the Czechoslovak Oriental Institut, no. 1-
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