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Peace at Alamein
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Protein Degradation with New Chemical Modalities
Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally 'difficult to target' proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.
Phenotypic Drug Discovery
Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of novel medical entities. This book aims to equip researchers with a thought-provoking guide to the application and development of contemporary phenotypic drug discovery for clinical success.
The Discovery and Utility of Chemical Probes in Target Discovery
Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.
Twentieth-century Italian Literature in English Translation
This bibliography lists English-language translations of twentieth-century Italian literature published chiefly in book form between 1929 and 1997, encompassing fiction, poetry, plays, screenplays, librettos, journals and diaries, and correspondence.
Alamein
El Alamein was one of the pivotal battles of the Second World War, fought by armies and air forces on the cutting edge of military technology. Yet Alamein has always had a patchy reputation - with many commentators willing to knock its importance. This book explains just why El Alamein is such a controversial battle. Based on an intensive reading of the contemporary sources, in particular the extensive and recently declassified British bugging of Axis prisoners of war, military historian Simon Ball turns Alamein on its head, explaining it as a cultural defeat for Britain. Alamein is a military history of the battle - showing how different it looks stripped of later cultural excrescences. But it also shows how 'Alamein culture' saturated the post-war world, when archival sources mingled with film, novels, magazines, popular histories, and the rest of Alamein's footprint. Whether you are interested in the battle itself or its cultural afterlife, if you have an opinion about Alamein, you'll question it after reading this book.
Italian Literature since 1900 in English Translation 1929-2016
Providing the most complete record possible of texts by Italian writers active after 1900, this annotated bibliography covers over 4,800 distinct editions of writings by some 1,700 Italian authors. Many entries are accompanied by useful notes that provide information on the authors, works, translators, and the reception of the translations. This book includes the works of Pirandello, Calvino, Eco, and more recently, Andrea Camilleri and Valerio Manfredi. Together with Robin Healey's Italian Literature before 1900 in English Translation, also published by University of Toronto Press in 2011, this volume makes comprehensive information on translations from Italian accessible for schools, libraries, and those interested in comparative literature.
Pace a El Alamein
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