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Beyond the C
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GWAS of Thyroid Stimulating Hormone Highlights Pleiotropic Effects and Inverse Association with Thyroid Cancer
Abstract: Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify 74 genome-wide significant loci for TSH, of which 28 are previously unreported. Functional experiments show that the thyroglobulin protein-altering variants P118L and G67S impact thyroglobulin secretion. Phenome-wide association analysis in the UK Biobank demonstrates the pleiotropic effects of TSH-associated variants and a polygenic score for higher TSH levels is associated with a reduced risk of thyroid cancer in the UK Biobank and three other independent studies. Two-sample Mendelian randomization using TSH index variants as instrumental variables suggests a protective effect of higher TSH levels (indicating lower thyroid function) on risk of thyroid cancer and goiter. Our findings highlight the pleiotropic effects of TSH-associated variants on thyroid function and growth of malignant and benign thyroid tumors
The End of Aspiration?
Why is it getting harder to secure a job that matches our qualifications, buy a home of our own and achieve financial stability? Underprivileged people have always faced barriers, but people from middle-income families are increasingly more likely to slide down the social scale than climb up. Duncan Exley, former Director of the Equality Trust, draws on expert research and real life experiences – including from an actor, a politician, a billionaire entrepreneur and a surgeon – to issue a wake-up call to break through segregated opportunity. He offers a manifesto to reboot our prospects and benefit all.
A Republic of Equals
The author traces the massive income inequality observed in the U.S. and other rich democracies to politicized markets and avoidable gaps in opportunity--and explains why they are the root cause of what ails democracy today.oday.
M-Theory and Quantum Geometry
The fundamental structure of matter and spacetime at the shortest length scales remains an exciting frontier of basic research in theoretical physics. A unifying theme in this area is the quantization of geometrical objects. The majority of lectures at the Advanced Study Institute on Quantum Ge ometry in Akureyri was on recent advances in superstring theory, which is the leading candidate for a unified description of all known elementary par ticles and interactions. The geometric concept of one-dimensional extended objects, or strings, has always been at the core of superstring theory but in recent years the focus has shifted to include also higher-dimensional ob jects, so called D-branes, which play a key role in the non-perturbative dynamics of the theory. A related development has seen the strong coupling regime of a given string theory identified with the weak coupling regime of what was previ ously believed to be a different theory, and a web of such" dualities" that interrelates all known superstring theories has emerged. The resulting uni fied theoretical framework, termed M-theory, has evolved at a rapid pace in recent years.
Are Racists Crazy?
The connection and science behind race, racism, and mental illness In 2012, an interdisciplinary team of scientists at the University of Oxford reported that - based on their clinical experiment - the beta-blocker drug, Propranolol, could reduce implicit racial bias among its users. Shortly after the experiment, an article in Time Magazine cited the study, posing the question: Is racism becoming a mental illness? In Are Racists Crazy? Sander Gilman and James Thomas trace the idea of race and racism as psychopathological categories., from mid-19th century Europe, to contemporary America, up to the aforementioned clinical experiment at the University of Oxford, and ask a slightly different que...
Elementary Introduction to Quantum Geometry
This graduate textbook provides an introduction to quantum gravity, when spacetime is two-dimensional. The quantization of gravity is the main missing piece of theoretical physics, but in two dimensions it can be done explicitly with elementary mathematical tools, but it still has most of the conceptional riddles present in higher dimensional (not yet known) quantum gravity. It provides an introduction to a very interdisciplinary field, uniting physics (quantum geometry) and mathematics (combinatorics) in a non-technical way, requiring no prior knowledge of quantum field theory or general relativity. Using the path integral, the chapters provide self-contained descriptions of random walks, r...
