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EDITOR: Prof. Dr. Kültegin ÖGEL ASSISTANT EDITOR: Burcu ÇETİN ŞEKER PREPARED BY: G. Melike ŞİMŞEK Gizem DEĞİRMENCİ Gaye KAĞAN N. Kübra SOLMAZ Büşra KAHRAMAN Emre YILMAZ Onur AYDIN Hilal SÖNMEZ Melekcan KABİL Nur KASSEM Zülal VATANSEVER Begüm KOÇER Ömer Faruk BOZDOĞAN GRAPHIC DESIGNER: Esra TOKAR
Imagine watching pounds of fat melt away without ever feeling like you're on a diet. Imagine adding lean muscle to all the right places by doing just a few workouts per week that make you strong. And imagine realizing that your health and fitness goals--even the ones you've all but given up on--are finally within your reach. Muscle for Life will show you how. From the bestselling fitness author of Bigger Leaner Stronger and The Shredded Chef, Muscle for Life reveals a science-based blueprint for eating and exercising that anyone can follow at any age and fitness level. Based on time-proven principles produced by decades of hands-on experience and thousands of hours of scientific research, Mu...
This study examines for the first time the finance procedures and documents of the post-classical Ottoman Empire. It provides an overview of institutional and monetary history and a detailed description of assessment and collection processes for Cizye, Avariz and Iltizam-collected taxes, the documents produced by these processes, and the information they contain. The finance department's detailed record-keeping, procedural continuity, and provision of economic justice made it a bulwark of stability in a period of turmoil. For specialists, this book introduces a multitude of sources on the economic and social history of the post-classical age, while for comparativists it places the empire in its seventeenth-century context. It links Ottoman administrative change with early modern state formation and reformulates the seventeenth century as a period of consolidation, not decline.
These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, ...
Abstract: Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify 74 genome-wide significant loci for TSH, of which 28 are previously unreported. Functional experiments show that the thyroglobulin protein-altering variants P118L and G67S impact thyroglobulin secretion. Phenome-wide association analysis in the UK Biobank demonstrates the pleiotropic effects of TSH-associated variants and a polygenic score for higher TSH levels is associated with a reduced risk of thyroid cancer in the UK Biobank and three other independent studies. Two-sample Mendelian randomization using TSH index variants as instrumental variables suggests a protective effect of higher TSH levels (indicating lower thyroid function) on risk of thyroid cancer and goiter. Our findings highlight the pleiotropic effects of TSH-associated variants on thyroid function and growth of malignant and benign thyroid tumors
Dünyaya Kuşbakışı Yapmak (1990-2017) - Türkiye'nin Dış Politikası
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