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Primary Immunodeficiency Diseases
Primary immunodeficiency diseases, first recognized 60 years ago, are inherited disorders that affect human adaptive and innate immunity. In most cases, affected individuals experience recurrent infections, but they may also suffer from autoimmune diseases and malignancies. This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases. With up-to-date diagnostic tools and therapeutic options -- from prophylactic anti-infective measures to hematopoietic stem cell transplantation and gene therapy -- this volume will remain an authoritative resource on this increasingly important area.
Primary Immunodeficiency Diseases
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
Solange bei der Bekämpfung von Schlafstörungen mit Arzneimitteln kein Mißbrauch getrieben wird, ist die Gefahr schädlicher Nebenwir kungen gering. Sehr häufig ist aber eine eintretende Gewöhnung durch Änderung der Reaktion des ZNS auf das Hypnotikum oder durch Be schleunigung des Abbaus der Anlaß zu einer Dosissteigerung, wodurch unerwünschte Wirkungen zunehmen. Sehr viele Schlafmittel, die nicht zur Gruppe der Barbiturate gehören, besitzen erst in höheren Dosierungen, welche die empfohlenen Dosen häufig übersteigen, eine objektiv feststellbare hypnotische Wirkung und entsprechende Nebenwirkungen. "Barbituratfrei" bedeutet daher keines falls eine bessere Verträglichkeit. Die gl...
2009
Up-to-date information on some 5,500 institutions and approx. 8,000 persons in public life in Hesse: authorities and departments of local, state and federal administration; jurisdiction; syndicates and other organizations from politics, business, academic life, the arts etc.; notaries, church offices, schools, universities, museums, libraries, hospitals, banks; mayors, District Administrators, chairpersons, presidents, directors, managing directors and other executives.
