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Nanoparticles in Cancer Therapy: Novel Concepts, Mechanisms and Applications
Since the invention of nanomedicine decades ago, considerable progresses have been made, especially with cancer as a target. Nanoparticles have been proven to be powerful imaging tools or potent agents for cancer diagnosis, treatment and prevention. Active research spread from fundamental research to clinical investigations. This topic intends to cover several important aspects in this field including nanocarrier development, gene delivery, intrinsically active nanoparticles, tumor microenvironment, immunology, and toxicity.
MOGAD, Current Knowledge and Future Trends
Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOGAD) is a neurological, immune-mediated disorder targeting MOG protein, located on the outermost myelin sheaths in the central nervous system. The diagnosis is confirmed when serum MOG antibody is found in patients in the context of inflammatory attacks of the central nervous system, usually with the brain, brainstem, optic nerve, and spinal cord. Although MOGAD manifestations can fulfill diagnostic criteria for Neuromyelitis optica disorder (NMOSD), evidence suggests that they have distinct immunological mechanisms. Similar to NMOSD, patients with persistent MOG antibodies are at risk for recurrent events. Recovery of MOGAD is generally reasonable. However, some patients get disability after a severe acute attack. Treatment for an acute attack is typically intravenous high-dose steroids, plasma exchange (PLEX), or intravenous immunoglobulin (IVIG). Maintenance therapy with immunosuppressants, i.e., azathioprine, mycophenolate, rituximab, etc., usually prevents future attacks, although they have long-term side effects. Therefore, it is still controversial how long treatment should be continued.
Making Autocracy Work
This book uses original data from China's National People's Congress to challenge conceptions of representation, authoritarianism, and the political system.
Multiple Sclerosis and Related Disorders: Challenges and Approaches to Mechanisms, Biomarkers, and Therapeutic Targets
Multiple sclerosis (MS) is an autoimmune condition that causes inflammatory damage to the central nervous system. The pathologic features are diffuse and focal inflammation, demyelination, gliosis, and neuronal damage in the optic nerves, brain, and spinal cord. Multiple sclerosis remains a challenging and disabling disease. There is a greater understanding of the underlying genetic and environmental factors driving the disorder, including low vitamin D levels, smoking, and obesity. Early and accurate diagnosis is essential and needs to be supported by diagnostic criteria, including imaging and spinal fluid abnormalities in patients with clinically isolated syndromes. Other demyelinating diseases are neuromyelitis optica spectrum disorders (NMOSD), anti-myelin oligodendrocyte glycoprotein antibody disease (MOGAD), and acute disseminated encephalomyelitis (ADEM).
Novel Treatment of Epilepsy
Epilepsy continues to be a major health problem throughout the planet, affecting millions of people, mainly in developing countries where parasitic zoonoses are more common and cysticercosis, as a leading cause, is endemic. There is epidemiological evidence for an increasing prevalence of epilepsy throughout the world, and evidence of increasing morbidity and mortality in many countries as a consequence of higher incidence of infectious diseases, head injury and stroke. We decided to edit this book because we identified another way to approach this problem, covering aspects of the treatment of epilepsy based on the most recent technological results "in vitro" from developed countries, and the basic treatment of epilepsy at the primary care level in rural areas of South Africa. Therefore, apart from the classic issues that cannot be missing in any book about epilepsy, we introduced novel aspects related with epilepsy and neurocysticercosis, as a leading cause of epilepsy in developing countries. Many experts from the field of epilepsy worked hard on this publication to provide valuable updated information about the treatment of epilepsy and other related problems.
The Frontier of Education Reform and Development in China
This book is a collection of academic articles selected from papers published in the Chinese journal Educational Research in 2021-2022. Educational Research was first published in 1979 and is a national, comprehensive, and theoretical journal of education research. It is sponsored by the Ministry of Education of the People's Republic of China and the China National Academy of Educational Sciences (CNAES). This book presents 20 important educational research articles and covers topics such as educational policies, education technologies, teacher education, and moral education. This book showcases a curated selection of education research outcomes in China and aids readers in developing a comprehensive understanding of China's education reform and development.
Advances in Anticancer Agents in Medicinal Chemistry
Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The first volume gathers reviews of many classes of drugs of contemporary interest for cancer therapy and is devoted to small molecules inhibitors of various proteins involved in cancer development such as Casein kinase 2 (CK2), Protein kinase B (PKB), mTOR, Hsp90, P-glycoprotein (P-gp), Kinesin spindle protein (KSP), Cyclooxygenase 2 (COX-2), Histone deacetylase enzymes (HDACs) and Topoisomerase I. Advances in Anticancer Agents in Medicinal Chemistry will be of particular interest to readers interested in anti cancer drug therapy as the series provides additional value to scientific research by entailing an approach of bringing relevant reviews up-to-date and thus more valuable for reference purposes.
