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Biomarkers, Functional Mechanisms, and Therapeutic Potentials in Gastrointestinal Cancers
Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of novel biomarkers and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnostic/prognostic factors, biomarkers, and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as th...
The Dreaming Mind and the End of the Ming World
From the mid-sixteenth through the end of the seventeenth century, Chinese intellectuals attended more to dreams and dreaming—and in a wider array of genres—than in any other period of Chinese history. Taking the approach of cultural history, this ambitious yet accessible work aims both to describe the most salient aspects of this “dream arc” and to explain its trajectory in time through the writings, arts, and practices of well-known thinkers, religionists, litterateurs, memoirists, painters, doctors, and political figures of late Ming and early Qing times. The volume’s encompassing thesis asserts that certain associations of dreaming, grounded in the neurophysiology of the human ...
Writing and Materiality in China
Speaking about Chinese writing entails thinking about how writing speaks through various media. In the guises of the written character and its imprints, traces, or ruins, writing is more than textuality. The goal of this volume is to consider the relationship of writing to materiality in China’s literary history and to ponder the physical aspects of the production and circulation of writing. To speak of the thing-ness of writing is to understand it as a thing in constant motion, transported from one place or time to another, one genre or medium to another, one person or public to another. Thinking about writing as the material product of a culture shifts the emphasis from the author as the creator and ultimate arbiter of a text’s meaning to the editors, publishers, collectors, and readers through whose hands a text is reshaped, disseminated, and given new meanings. By yoking writing and materiality, the contributors to this volume aim to bypass the tendency to oppose form and content, words and things, documents and artifacts, to rethink key issues in the interpretation of Chinese literary and visual culture.
Biomarkers and Immunotherapy of Hepatic-Biliary-Pancreatic Cancers
Hepatic-biliary-pancreatic cancers, mainly including hepatocellular carcinoma, cholangiocarcinoma, gallbladder cancer, are highly aggressive malignancies with few treatment options and poor prognoses. Effects of the traditional systemic treatments such as chemotherapy and radiotherapy, are quite limited to hepatic-biliary-pancreatic cancers. For the patients who suffer from hepatic-biliary-pancreatic cancer and lose the opportunity of radical surgery, few targeted drugs are available. Even for the drugs in clinical trial, potential drug targets and prognostic biomarkers for hepatic-biliary-pancreatic cancer are less studied compared to other common cancers such as lung cancer. Prognostic bio...
The immunological regulation of extracellular vesicles on chronic diseases
With the transformation of the human disease spectrum, chronic non-infectious diseases have become the main killer of human health in modern society. The interaction between genes and the environment will cause the body’s immune function to be disordered, thereby affecting the body's homeostasis and causing various chronic non-infectious diseases. It has been revealed that the occurrence and development of most chronic diseases, such as cancer, cardiac disease, diabetes mellitus, autoimmune disease, and neuroimmune disorders, are associated with the dysregulation of the immune system.
