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Interleukin-5
This important volume describes the latest advances in all areas of interleukin-5 (IL5) research, pooling the insights of over 65 biological researchers, pharmaceutical scientists, and clinicians, representing institutions as diverse as the Mayo Clinic, the National Lung and Heart Institute, the John Curtin School of Medical Research, the Geneva Biomedical Research Institute, the Flanders' Interuniversity Institute for Biotechnology, and the University of Tokyo. Details IL5-related antiallergy drugs currently in development at Glaxo Wellcome and Schering-Plough Research Institute! Reviewing approaches toward small molecule antagonists and inhibitors, Interleukin-5 highlights the structure an...
Interleukin-5 and Interleukin-5 Receptor Polymorphism in Asthma
Asthma is a common chronic inflammatory disease of the airways of the lungs, in the world. It,Äôs associated with type 2 cytokines interleukin-4, IL-5, and IL-13, which promote airway eosinophilia, bronchial hyperresponsiveness, mucus overproduction, and immunogloubulin E synthesis. IL-5 is a cytokine known to play major role in the regulation of eosinophil formation, maturation, survival, and recruitment. Hence, an increased production of IL-5 may be contributed to the pathogenesis of asthma. The expression of human IL-5 receptor presented on eosinophils, basophils, and mast cells. Hence, a polymorphism in IL-5 receptor may be implicated in the development of asthma. Many candidate genes ...
Interleukin-5 Family Cytokine Induced Signaling in Human Primary Eosinophils
Allergic asthma is a prevalent, chronic respiratory disorder marked by inflammation, elevated inflammatory mediators (e.g., interleukin-5 [IL-5] family cytokines), and increased eosinophil (EOS) numbers. EOS recruitment and inflammatory response contributes to asthma-associated airway damage. Given EOS dependence on IL-5 cytokines for growth, development, and inflammatory behavior, improved treatments for eosinophil-related diseases require further elucidating IL-5 family-induced intracellular signaling. Relative to peripheral blood eosinophils (EOSPB), IL-5 family-induced survival is abated in airway eosinophils (EOSA) though EOSA remain responsive to IL-5 cytokines for certain inflammatory...
Structure/function Analysis of Interleukin 5 and Its Receptor
For the beta chain, differences in IL5 activity between m[beta] [subscript]com. and m[beta] [subscript]IL3 were used to identify an IL5 contact point. Using chimeras of these molecules, residues within the B-C loop of FnIII domain 4 of m[beta] [subscript]com were identified which are required for IL5 interaction.
