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Peritoneal Carcinomatosis: Principles of Management
Paul Sugarbaker and his colleagues have persevered in the study and treat ment of peritoneal carcinomatosis. The peritoneal cavity has many unique and incompletely appreciated properties. These properties, coupled with the biologic behavior of many cancers, results in the seeding and growth of these cancers on the peritoneum. Many of these cancers remain localized to the peritoneum only, never metastasizing to other sites. One possible reason for this may be the obstruction of the afferent lymphatics on the undersurface of the diaphragm. The mucopolysaccharides produced by many of these neoplasma are probably viscous enough to obstruct these lymphatics, leading to the syndrome of pseudomyxom...
Targeting of Drugs With Synthetic Systems
Targeting of drugs via carrier systems to sites in the body in need of pharmacologic intervention is a rapidly growing area of research in the treatment or prevention of disease. It has evolved from the need to preferentially deliver drugs, enzymes, vitamins, hormones, antigens, etc. to target cells and organs so as to avoid toxicity, waste of drugs through premature secretion or inactivation and at the same time render treatment more convenient and cost-effective. A wide assortment of naturally occ urring or semi-synthetic drug carriers (e. g. antibodies, glycoproteins, lectins, peptide hormones, cells and liposomes), their inter action with relevant receptors and mediation of optimal pharm...
Technological Applications of Dispersions
"This comprehensive guide illustrates the effects of dispersions in applications, the means necessary to achieve these effects with optical results, and how to overcome or avoid the difficulties encounteredemphasizing the dispersions of solid particles in liquid or solid media."
Antitumor Drug Resistance
The study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J. H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of resistance to most of the well-known anticancer agents in many different animal tumour systems, both in vivo and in vitro. Many different mechanisms of resistance have been described, and it is clear that the tumour cell has a wide diversity of options in overcoming the cell-killing activity of these agents. Definition of the magnitude of the phenomenon in the clinic is, however, much more problematical, and it is with this in mind that the initi...
Colloidal Drug Delivery Systems
This volume provides a single-source of reviews for all the important colloidal drug delivery systems, including nanoparticles, liposomes, niosomes, microemulsions and ointments. Over 1000 bibliographic citations, as well as tables, drawings, equations and photographs, are provided. Arranged in order of increasing physical complexity, this work ana
Interfacial Phenomena in Drug Delivery and Targeting
This book series aims to provide a comprehensive survey for senior undergraduates, graduates and established workers carrying out research in drug delivery and targeting in its many facets.
Oxidative Stress in Cancer Biology and Therapy
During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxida...
Towards Coordination of Cancer Research in Europe
A rapid exchange of information between European research institutes greatly enhances the national effectiveness of individual programmes to the prevention and treatment of cancer.
