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Immune Escape Pathways from the HBV Core18-27 CD8 T Cell Response are Driven by Individual HLA Class I Alleles
Abstract: Background and aims: There is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells. All these approaches depend on recognition of HLA class I-presented viral peptides. The HBV core region 18-27 is an immunodominant target of CD8+ T cells and represents the prime target for T cell-based therapies. Here, a high-resolution analysis of the core18-27 specific CD8+ T cell and the selected escape pathways was performed. Methods: HLA class I typing and viral sequence analyses were performed for 464 patients with chronic HBV infection. HBV-specific CD8+ T-cell...
Data Integration in the Life Sciences
This book constitutes the refereed proceedings of the Third International Workshop on Data Integration in the Life Sciences, DILS 2006, held in Hinxton, UK in July 2006. Presents 19 revised full papers and 4 revised short papers together with 2 keynote talks, addressing current issues in data integration from the life science point of view. The papers are organized in topical sections on data integration, text mining, systems, and workflow.
Clinical PET/MRI
Clinical PET/MR presents the state-of-the-art of PET/MR, guiding the reader from how to scan patients, how to read and report the studies, and how keep an eye on what is clinically relevant for a patient's care. Each chapter starts with the clinical scenario and then moves to pertinent imaging, addressing the need of a clinical PET/MR book written by world experts in both clinical and imaging fields. It discusses the clinical application of PET/MR in diverse subspecialties such as head and neck, neurology, cardiovascular, pediatrics, chest, bone, hematology, breast, hepatobiliary pancreatic, genitourinary, gynecology, and gastrointestinal tract. This book is a valuable resource for radiologists, oncologists and members of the biomedical field who need to learn more about clinical applications of PET/MR. Presents a description of robust acquisition protocols to teach readers how to scan PET/MR patients, from tracers to sequences Provides a clinical background section in each chapter to help readers focus on the real clinical issues that need to be addressed in the medical report Written by world authorities in the field in a didactic manner to describe the real status of imaging
Applications of Evolutionary Computation
This book constitutes the refereed proceedings of the 22nd International Conference on Applications of Evolutionary Computation, EvoApplications 2019, held in Leipzig, Germany, in April 2019, co-located with the Evo*2019 events EuroGP, EvoCOP and EvoMUSART. The 44 revised full papers presented were carefully reviewed and selected from 66 submissions. They were organized in topical sections named: Engineering and Real World Applications; Games; General; Image and Signal Processing; Life Sciences; Networks and Distributed Systems; Neuroevolution and Data Analytics; Numerical Optimization: Theory, Benchmarks, and Applications; Robotics. --
The Nexus: Energy, Environment and Climate Change
This book focuses on the water–energy–climate nexus, which can be used to improve energy security and quality of life for millions of people in developing countries. It enhances the reader’s understanding of the link between energy and climate, through the development of new approaches to and methods for energy generation, energy use, and climate change adaptation and resilience. By presenting case studies and research reports, the book addresses the relevant issues needed in order to analyze and successfully implement technologies in the water–energy–climate nexus. It focuses on the contributions of higher education institutions in terms of capacity-building for energy efficiency,...
