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Immune Escape Pathways from the HBV Core18-27 CD8 T Cell Response are Driven by Individual HLA Class I Alleles
Abstract: Background and aims: There is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells. All these approaches depend on recognition of HLA class I-presented viral peptides. The HBV core region 18-27 is an immunodominant target of CD8+ T cells and represents the prime target for T cell-based therapies. Here, a high-resolution analysis of the core18-27 specific CD8+ T cell and the selected escape pathways was performed. Methods: HLA class I typing and viral sequence analyses were performed for 464 patients with chronic HBV infection. HBV-specific CD8+ T-cell...
Granule Cell Dispersion in Two Mouse Models of Temporal Lobe Epilepsy and Reeler Mice is Associated with Changes in Dendritic Orientation and Spine Distribution
Abstract: Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein Reelin, which regulates neuron migration and dendrite outgrow. Reelin-deficient (reeler) mice show no layering, their granule cells are dispersed throughout the dentate gyrus. We studied granule cell dendritic orientation and distribution of postsynaptic spines in reeler mice and two mouse models of temporal lobe epilepsy, namely the p35 knockout mice, which show Reelin-independent neuronal migration defects, and mice with unilateral intrahippocampal kai...
Principles of Historical Linguistics
Historical linguistic theory and practice contains a great number of different 'layers' which have been accepted in the course of time and have acquired a permanency of their own. These range from neogrammarian conceptualizations of sound change and analogy to present-day ideas on rule change and language mixture. To get a full grasp of the principles of historical linguistics it is therefore necessary to understand the nature and justifications (or shortcomings) of each of these 'layers', not just to look for a single 'overarching' theory. The major purpose of the book is to provide in up-to-date form such an understanding of the principles of historical linguistics and the related fields of comparative linguistics and linguistic reconstruction. In addition, the book provides a very broad exemplification of the principles of historical linguistics.
The SA Generals and the Rise of Nazism
No part of the Nazi movement contributed more to Hitler's success than the Sturmabteilung (SA) -- the notorious Brown Shirts. Bruce Campbell offers the first in-depth study in English of the men who held the three highest ranks in the SA. Organized on military lines and fired by radical nationalism, the Brown Shirts saw themselves as Germany's paramilitary saviors. Campbell reveals that the homogeneity of the SA leadership was based not on class or status, but on common experiences and training. Unlike other investigations of the Nazi party, The SA Generals and the Rise of Nazism focuses on the military and political activities of the Brown Shirts to show how they developed into SA Leaders. ...
Government Gazette
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The Weirdest People in the World
'A landmark in social thought. Henrich may go down as the most influential social scientist of the first half of the twenty-first century' MATTHEW SYED Do you identify yourself by your profession or achievements, rather than your family network? Do you cultivate your unique attributes and goals? If so, perhaps you are WEIRD: raised in a society that is Western, Educated, Industrialized, Rich and Democratic. Unlike most who have ever lived, WEIRD people are highly individualistic, nonconformist, analytical and control-oriented. How did WEIRD populations become so psychologically peculiar? What part did these differences play in our history, and what do they mean for our collective identity? J...
Eighteenth Century Emigrants from the Northern Alsace to America
Each family group record in this impressive volume includes the name(s) of the immigrant(s), ship arrival data, European villages of origin (including earlier Swiss residences where given), data on each family from the European church registers, as well as information on many of the 628 families after their arrival in America. (690pp. illus. index. hardcover. Author, 1992.)
