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Constraint Databases and Applications
The ?rst International Symposium on the Applications of Constraint Databases (CDB2004) took place in Paris, France, on June 12–13, 2004, just before the ACM SIGMOD and PODS conferences. Since the publication of the paper “Constraint Query Languages” by Kan- lakis, Kuper and Revesz in 1990, the last decade has seen a growing interest in constraint database theory, query evaluation, and applications, re?ected in a variety of conferences, journals, and books. Constraint databases have proven to be extremely ?exible and adoptable in environments that relational database systems cannot serve well, such as geographic information systems and bioinf- matics. This symposium brought together peo...
Foundations of Computational Mathematics, Santander 2005
Surveys and summaries of latest research in numerical analysis, optimization, computer algebra and scientific computing.
Dissociative States
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Foundations of Computational Mathematics
Collection of papers by leading researchers in computational mathematics, suitable for graduate students and researchers.
Reverse Phase Protein Arrays
This book provides practical guidance on all aspects of reverse phase protein array (RPPA) technology, which permits the quantification of protein levels in cell or tissue lysates. In addition, the latest results are presented from laboratories across the world where experts are successfully running the challenging RPPA data platform. After an introductory chapter by the inventor of the RPPA technique, the demanding task of lysate preparation is explained. Subsequent chapters review printing platforms and analytical platforms and discuss antibody screening in detail. The role of RPPA data in integrative analyses is thoroughly examined, and the various applications of RPPA, for example to identify molecular targeting drugs or evaluate cancer drug efficacy, are discussed with reference to the latest knowledge. It is hoped that the book will foster the implementation of RPPA by documenting the practical details of the technology and by revealing its great potential. It will be of high value for researchers who plan to build an RPPA platform in their institute and for researchers, clinicians, and companies who use RPPA through collaboration with an existing RPPA facility.
Pharmacokinetics in Drug Development
In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.
Targeting PI3K/mTOR signaling in cancer
The phosphatidylinositol 3-kinase (PI3K)/mTOR pathway integrates signals from growth factors with nutrient signals and other conditions and controls multiple cell responses, including proliferation, survival and metabolism. Deregulation of the PI3K pathway has been extensively investigated in connection to cancer. Somatic or inherited mutations frequently occur in tumor suppressor genes (PTEN, TSC1/2, LKB1) and oncogenes (PIK3CA, PIK3R1, AKT) in the PI3K/mTOR pathway. The fact that the PI3K/mTOR pathway is deregulated in a large number of human malignancies, and its importance for different cellular responses, makes it an attractive drug target. Pharmacological PI3K inhibitors have played a ...
Managing the Drug Discovery Process
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at th...
Applied Algebra, Algebraic Algorithms and Error-Correcting Codes
This book constitutes the proceedings of the 11th International Conference on Applied Algebra, Algebraic Algorithms and Error-Correcting Codes, AAECC-11, held in Paris, France in July 1995. The volume presents five invited papers and 32 full revised research papers selected from a total of 68 submissions; it is focussed on research directed to the exploitation of algebraic techniques and methodologies for the application in coding and computer algebra. Among the topics covered are coding, cryptoloy, communication, factorization of polynomials, Gröbner bases, computer algebra, algebraic algorithms, symbolic computation, algebraic manipulation.
Industrial Applications
This volume gives a survey of the state of the art in the traditional fields of industrial mycology as well as of selected novel applications of fungi. The first section deals with the use of fungi in the production and processing of bread, cheese, beer and wine, traditional Asian fermentation products and edible mushrooms. The second section is devoted to the production of fungal metabolites and enzymes representing value-added products. In addition to antibiotics, alkaloids organic acids, vitamins and industrial enzymes, which have successfully been in use for decades, it is also dedicated to fungal metabolites, such as insecticidal and nematicidal compounds, immunosurppressants and flavor...
