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Molecular Pathogenesis of Neisseria Gonorrhoeae
This Research Topic is dedicated to our current understanding of the molecular pathogenesis of Neisseria gonorrhoeae. Topics in this issue include the following: human infection models for testing gonococcal virulence, animal models that mimic lower female genital tract infection, and an ex vivo system derived from the human female lower genital tract. Vaccine development efforts, and the impact of gonococcal infection on the host's immune response are also described. Also part of this issue are reviews of the molecular aspects of several important virulence factors, including: biofilm formation, neutrophil resistance, innate immune factor resistance, iron acquisition, and type 4 secretion systems.
Outside In
Publikace vypráví o historii Katedry anglistiky a amerikanistiky FF MU. Vyprávění je strukturované a je založeno na metodě orální historie. Vypravěčem je Don Sparling, osobnost dlouhodobě spjatá s životem katedry a její bývalý vedoucí. První kapitola líčí vznik Anglického semináře v roce 1920 pod vedením profesora Františka Chudoby a pokračuje popisem meziválečných událostí. Další kapitoly se věnují poválečnému období až do roku 1977 (příchod Dona Sparlinga na katedru), následně osmdesátým létům a době porevoluční do roku 2000. Poslední kapitola shrnuje dějiny významné součásti života katedry, divadelního spolku The Gypsywood Players.
Methods in Proteome and Protein Analysis
Following the succesful publication of "Proteome and Protein Analysis" in 2000, which was based on a former MPSA (Methods in Protein Structure Analysis) conference, "Methods in Proteome and Protein Analysis" presents the most interesting papers from the 14th MPSA meeting. Major topics include: X-ray crystallography, mass spectrometry or cryo-electron microscopy tomography and different experimental approaches for the study of very large multi-subunit molecular nanomaschines; development of high throughput methods for large-scale protein expression and purification and automatic data acquisition for structure determination by both X-ray diffraction and NMR spectroscopy; mechanisms of protein folding and misfolding in vitro and in vivo; protein-protein interactions; analysis of post-translational modifications; the classification, prediction of structure or functional sites, and evolution of protein folds and functions. TOC: Includes 25 chapters organized in the following parts: Structural Proteomics Proteome Analysis Structure-Function Correlations Protein-Protein Interaction Advanced Technologies Protein Sequencing and Amino Acids Analysis Bioinformatics
Vaccines
The immune system is the only organ system in the body besides the central nervous systems endowed with memory. Both types of memories are specific and long-lasting, sometimes life long. This memory capacity of the immune system provides the basis for the most cost-efficient of all medical interventions, successful vaccinations against many common infectious diseases. Such a success requires the isolation of the infectious agent or toxic substance, methods to grow and/or purify the relevant antigen and change it into something innocuous whilst maintaining its immunogenicity. Whereas the early vaccines could only use the enhanced resistance against infectious disease as a measure of vaccine e...
Executive Documents
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The Clinique
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