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Critical Issues in Head and Neck Oncology
This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.
Basic Clinical Radiobiology
The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy. As previously, a multi-national authorship includes some of the top radiation oncologists, biologists, and physicists from North America and Europe, who highlight the core principles of radiobiology.
Methods of Cancer Diagnosis, Therapy and Prognosis
This fourth volume in a series devoted to cancer treatment discusses various methodologies for the diagnosis, therapy and prognosis of colorectal cancer. It covers the latest information including standard and emerging therapies and technological advances.
Squamous cell Carcinoma
This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squa...
Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America
This issue of Hematology/Oncology Clinics of North America is devoted to Head and Neck Cancer. Guest Editor Alexander Colevas, MD has assembled a group of expert authors to review the following topics: Epidemiology of SCCHN; Genetics of Head and Neck Cancers; Molecular Biology of Head and Neck Cancers; Quality of Life in Head and Neck Cancer Treatment; Nasopharyngeal Carcinoma; Evolving Surgical Techniques in SCCHN; Radiation Oncology New Approaches in SCCHN; Thyroid Gland Malignancies; Sequential and Concurrent Chemoradiation; Systemic Chemotherapy for SCCHN Focus on New targets and Agents; EGFR Inhibition in SCCHN; Diagnostic and Therapeutic Assessment Imaging in Head and Neck Cancer; Salivary Gland Cancers; Immunotherapy in SCCHN; Human Papillomavirus in SCCHN; and Supportive Care Issues in SCCHN Treatment and Survivorship: Dental, Nutrition, Speech and Swallowing, Depression.
Translation and Its Regulation in Cancer Biology and Medicine
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the transla...
Pacific Symposium on Biocomputing 2008
The Pacific Symposium on Biocomputing (PSB) 2008 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2008 will be held on January 4?8, 2008 at the Fairmont Orchid, Big Island of Hawaii. Tutorials will be offered prior to the start of the conference.PSB 2008 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It...
International Manual of Oncology Practice
Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of...
Head and Neck Cancer
In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.
Immunotherapy for Head and Neck Cancer
This book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers. Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours ha...
