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Burden of Illness in People with Epilepsy: From Population-Based Studies to Precision Medicine
Epilepsy is a common and chronic neurological disease that is characterized by recurrent seizures which impose a major burden on patients, their caregivers, and society. Worldwide more than 39 million people are affected by epilepsy. The aim of this Research Topic was to provide evidence that personalized translational epilepsy research will benefit patients through targeted experimental, clinical and network research.
Sleep Quality, Anxiety, Symptoms of Depression, and Caregiver Burden Among Those Caring for Patients with Dravet Syndrome: a Prospective Multicenter Study in Germany
Abstract: Background This study measured sleep quality among caregivers of patients with Dravet syndrome (DS) and assessed the impacts of mental health problems and caregiver burden on sleep quality. Methods This multicenter, cross-sectional study of patients with DS and their caregivers throughout Germany consisted of a questionnaire and a prospective 4-week diary querying disease characteristics, demographic data, living conditions, nocturnal supervision, and caregivers' work situations. Sleep quality was assessed using the Pittsburgh Sleeping Quality Index (PSQI). The Hospital Anxiety and Depression Scale (HADS) and the Burden Scale for Family Caregivers (BSFC) were used to measure anxiet...
Direct and Indirect Costs and Cost-driving Factors in Adults with Tuberous Sclerosis Complex: a Multicenter Cohort Study and a Review of the Literature
Background: Tuberous sclerosis complex (TSC) is a monogenetic, multisystem disorder characterized by benign growths due to TSC1 or TSC2 mutations. This German multicenter study estimated the costs and related cost drivers associated with organ manifestations in adults with TSC. Methods: A validated, three-month, retrospective questionnaire assessed the sociodemographic and clinical characteristics, organ manifestations, direct, indirect, out-of-pocket (OOP), and nursing care-level costs among adult individuals with TSC throughout Germany from a societal perspective (costing year: 2019). Results: We enrolled 192 adults with TSC (mean age: 33.4)±)12.7 years; range: 18-78 years, 51.6% [n)=)99]...
Epilepsy: A Comprehensive Textbook
Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.
Local Glucose Metabolism is Unaltered in Reversible Splenial Lesion Syndrome
Background and purpose: Transient splenial oedema, also known as reversible splenial lesion syndrome (RESLES), is a rare magnetic resonance imaging (MRI) finding that presents as a round or ovoid focal oedema in the posterior corpus callosum, and is associated with a wide range of clinical conditions. The aetiology of RESLES is not fully clear. We aimed to investigate conflicting pathophysiological hypotheses by measuring local glucose metabolism in patients with RESLES. Methods: We retrospectively analysed patients with RESLES after reductions in antiseizure medications during in-hospital video electroencephalography monitoring. We measured local glucose uptake using positron emission tomog...
