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Us and Them chronicles the depth to which Canada and Canadians were part of The Beatles’ story—their formation, growth and break up. Entertaining and well researched, Us and Them places John, Paul, George and Ringo as a band and as solo artists in a uniquely Canadian setting; it blends rich stories, facts, analysis, and even dabbles in several plausible but little known accounts that create a new ripple in The Beatles’ history. After consuming Us and Them, readers will never again listen to albums Sgt. Pepper’s Lonely Hearts Club Band and the White Album, or singles “Come Together”, “Give Peace a Chance”, “All Things Must Pass”, “Imagine” and “Mull of Kintyre” without thinking about these masterworks in a Canadian context. Us and Them is a thorough account of the Fab Four's relationship with Canada, filling an important gap in their narrative and discography.
Us and Them chronicles the depth to which Canada and Canadians were part of The Beatles' story-their formation, growth and break up. Entertaining and well researched, Us and Them places John, Paul, George and Ringo as a band and as solo artists in a uniquely Canadian setting; it blends rich stories, facts, analysis, and even dabbles in several plausible but little known accounts that create a new ripple in The Beatles' history. After consuming Us and Them, readers will never again listen to albums Sgt. Pepper's Lonely Hearts Club Band and the White Album, or singles "Come Together", "Give Peace a Chance", "All Things Must Pass", "Imagine" and "Mull of Kintyre" without thinking about these masterworks in a Canadian context. Us and Them is a thorough account of the Fab Four's relationship with Canada, filling an important gap in their narrative and discography.
One of few books to cover all aspects of cyclin-dependent kinases (CDKs), this volume examines CDKs as molecular and functional entities, their role in various disease processes, and their potential for pharmacological modulation. The book first explains the integration of cell cycle control pathways, opportunities for targeting, targets of inhibitors, and the evaluation of CDK inhibitors. Then it examines the design, development, and chemistry of small molecule CDK inhibitors. The final section assesses the current status of CDK inhibitors in clinical trials, the therapeutic deployment challenges of small molecule inhibitors, and the future prospects of CDK inhibitors as anticancer agents.
Over the past decade renewed interest in practical applications of Earth observations from space has coincided with and been fueled by significant improvements in the availability of remote sensing data and in their spectral and spatial resolution. In addition, advances in complementary spatial data technologies such as geographic information systems and the Global Positioning System have permitted more varied uses of the data. During the same period, the institutions that produce remote sensing data have also become more diversified. In the United States, satellite remote sensing was until recently dominated largely by federal agencies and their private sector contractors. However, private ...
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