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Material-based Mechanobiology
Mechanobiology is a new research field that investigates how the physical forces and changes in mechanical properties of cells and tissues contribute to their development, physiology and disease. One unique feature in the mechanical regulation, distinct from chemical/biochemical one, is that it can directly react with the multi-layered architectures of living systems, ranging from nano-scale proteins, subcellular organelles, cells, tissues, organs to whole bodies; one could term it “mechanoarchitectonics”. Another important aspect is its time-dependent dynamic feature. Not only time evolution in cells and extracellular matrices, but their intrinsic viscoelastic nature makes mechanical in...
GMP Horizons
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Global Tuberculosis Report 2017
WHO's Global Tuberculosis Report provides a comprehensive and up-to-date assessment of the TB epidemic and of progress in care and prevention at global, regional and country levels. This is done in the context of recommended global TB strategies and associated targets, and broader development goals. For the period 2016-2035, these are WHO's End TB Strategy and the United Nations' (UN) Sustainable Development Goals (SDGs), which share a common aim: to end the global TB epidemic. The main data sources for the report are annual rounds of global TB data collection implemented by WHO's Global TB Program since 1995 and databases maintained by other WHO departments, UNAIDS and the World Bank. In WHO's 2017 round of global TB data collection, 201 countries and territories that account for over 99% of the world's population and TB cases reported data.
Analyse und Optimierung von AlGaN/GaN-HEMTs in der leistungselektronischen Anwendung
Die Leit- und Schaltverluste eines Leistungshalbleiters haben nach wie vor einen entscheidenden Einfluss auf die Effizienz und die erreichbare Leistungsdichte eines Umrichters. Aktuell zeigen sich AlGaN/GaN-HEMTs vor allem durch ihre hohen Schaltgeschwindigkeiten bei gleichzeitig ausgezeichneten Leiteigenschaften als aussichtsreiche Kandidaten für eine Reduktion dieser Verluste. In dieser Arbeit werden neuartige GaN-Transistoren charakterisiert und für leistungselektronische Anwendungen optimiert. Der Schwerpunkt liegt dabei auf der gegenseitigen Anpassung der Halbleitertechnologie und der Schaltungsumgebung. Conduction and switching losses of power semiconductors still have decisive influence on the efficiency and achievable power density of a converter. AlGaN/GaN HEMTs are promising reduction of these losses due to their very high switching speeds and excellent conductivity. In this work novel GaN transistors are characterized and optimized for power electronic applications. The focus is on the mutual adaptation of the semiconductor technology and the circuit environment.
Split Inteins
This volume focuses on applications of split inteins, and the progress that has been made in the past 5 years on discovery and engineering of fast and more efficient split inteins. The first few chapters in Split Inteins: Methods and Protocols explore new techniques on how to use split inteins for affinity purification of overproduced proteins, and split-intein based technologies to prepare cyclic peptides and proteins. The next few chapters discuss semisynthetic protein trans-splicing using one synthetic intein piece, synthetic intein-extein pieces used to deliver other cargos for chemical modification both of purified proteins and of proteins in living cells, as well as isotopic labeling o...
