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Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in the development of novel therapeutic and preventive strategies. In this book, Professor zur Hausen (Nobel Prize in Physiology/Medicine 2008) provides a thorough and comprehensive overview on carcinogenic infective agents -- viruses, bacteria, parasites and protozoons -- as well as their corresponding transforming capacities and mechanisms. The result is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer. The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early as 1976, published the hypothesis that wart viruses play a role in the development of this type of cancer.
Containing reports from Pennsylvania judicial districts and other leading decisions.
During the second half of the 20th century, landmark works of the horror film genre were as much the product of enterprising regional filmmakers as of the major studios. From backwoods Utah to the Louisiana bayous to the outer boroughs of New York, independent, regional films like Night of the Living Dead, Last House on the Left, I Spit on Your Grave, The Texas Chain Saw Massacre, and The Evil Dead stood at the vanguard of horror cinema. This overview of regionally produced horror and science fiction films includes interviews with 13 directors and producers who operated far from mainstream Hollywood, along with a state-by-state listing of regionally produced genre films made between 1958 and 1990. Highlighting some of the most influential horror films of the past 50 years, this work celebrates not only regional filmmaking, but also a cultural regionalism that is in danger of vanishing.
This book provides a largely self-contained introduction to Cox rings and their applications in algebraic and arithmetic geometry.
Based on extensive archival research in six countries and intensive fieldwork, the book analyzes the history of the village of Nkholongue on the eastern (Mozambican) shores of Lake Malawi from the time of its formation in the 19th century to the present day. The study uses Nkholongue as a microhistorical lens to examine such diverse topics as the slave trade, the spread of Islam, colonization, subsistence production, counter-insurgency, decolonization, civil war, ecotourism, and matriliny. Thereby, the book attempts to reflect as much as possible on the generalizability and (global) comparability of local findings by framing analyses in historiographical discussions that aim to go beyond the...
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