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Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in the development of novel therapeutic and preventive strategies. In this book, Professor zur Hausen (Nobel Prize in Physiology/Medicine 2008) provides a thorough and comprehensive overview on carcinogenic infective agents -- viruses, bacteria, parasites and protozoons -- as well as their corresponding transforming capacities and mechanisms. The result is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer. The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early as 1976, published the hypothesis that wart viruses play a role in the development of this type of cancer.
Catching Cancer introduces readers to the investigators who created a medical revolution—a new way of looking at cancer and its causes. Featuring interviews with notable scientists such as Harald zur Hausen, Barry Marshall, Robin Warren, and others, the book tells the story of their struggles, their frustrations, and finally the breakthroughs that helped form some of the most profound changes in the way we view cancer. Claudia Cornwall takes readers inside the lab to reveal the long and winding path to discoveries that have changed and continue to alter the course of medical approaches to one of the most confounding diseases mankind has known. She tells the stories of families who have ben...
Topics covered range from an overview of the contribution of DNA tumour viruses to the cancer burden worldwide, and the molecular pathogenesis of virus driven cancers to vaccine development.
In The Beginner's Guide to Winning the Nobel Prize, Doherty recounts his unlikely path to becoming a Nobel Laureate. Beginning with his humble origins in Australia, he tells how he developed an interest in immunology and describes his award-winning, influential work with Rolf Zinkernagel on T-cells and the nature of immune defense. In prose that is at turns amusing and astute, Doherty reveals how his nonconformist upbringing, sense of being an outsider, and search for different perspectives have shaped his life and work. Doherty offers a rare, insider's look at the realities of being a research scientist. He lucidly explains his own scientific work and how research projects are selected, fun...
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
The never-before-told story of the horned rabbit—the myths, the hoaxes, and the entirely real scientific breakthroughs it has inspired—and how it became a cultural touchstone of the American West. Just what is a jackalope? Purported to be part jackrabbit and part antelope, the jackalope began as a local joke concocted by two young brothers in a small Wyoming town during the Great Depression. Their creation quickly spread around the U.S., where it now regularly appears as innumerable forms of kitsch—wall mounts, postcards, keychains, coffee mugs, shot glasses, and so on. A vast body of folk narratives has carried the jackalope’s fame around the world to inspire art, music, film, even ...
In 1961 John F. Kennedy pledged to put a man on the moon by the end of the decade. Nine years later, Neil Armstrong and Buzz Aldrin walked on the moon. Ten years later, Richard Nixon echoed this pledge by declaring a 'war' on cancer. More than 30 years later, however, cancer remains one of the largest causes of death worldwide, with around 1 in 3 developing the disease. Curing cancer is not 'rocket science', but the question is, why has cancer proved to be harder to tackle than the moon landings turned out to be? Cancer research is a major economic activity. There are constant improvements in treatment techniques that result in better cure rates and increased quality and quantity of life for...
The co-discoverer of HIV and one of the world's preeminent virologists relates the Pasteur Institute's leading role in investigating the AIDS virus and the virus's devastating course throughout the world. Photos.
Eleven years ago the circular DNA of a novel single-stranded virus has been cloned and partially characterized by Nishizawa and Okamoto and their colleagues. According to the initials of the patient from whom the isolate originated, the virus was named TT virus. This name has been subsequently changed by the International Committee on Taxonomy of Viruses (ICTV) into Torque teno virus, permitting the further use of the abbreviation TTV. Although initially suspected to play a role in non A –E hepatitis, subsequent studies failed to support this notion. Within a remarkably short period of time it became clear that TT viruses are widely spread globally, infect a large proportion of all human populations studied thus far and represent an extremely heterogeneous group of viruses, now labelled as Anelloviruses. TT virus-like infections have also been noted in various animal species. The classification of this virus group turns out to be difficult, their DNA contains between 2200 and 3800 nucleotides, related so-called TT-mini-viruses and a substantial proportion of intragenomic recombinants further complicate attempts to combine these viruses into a unifying phylogenetic concept.