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Near-infrared Photoimmunotherapy Targeting CD8 T Cells Inhibits Cutaneous Acute Graft-versus-host Disease
Near-infrared photoimmunotherapy (NIR-PIT) represents a novel antibody-based strategy for selective cellular depletion. Originally introduced for EGFR-specific cancer cell treatment, NIR-PIT displayed distinctive depletion prosperity in several mouse models. Adapted from these findings, a skin selective depletion of an antibody-targeted cell type has a potential of becoming an important therapeutic option in dermatology. Here, we report on a method for the skin selective depletion of CD8 T cells and its therapeutic effect in a humanized mouse model of cutaneous acute graft-versus-host disease (aGVHD). In immunodeficient NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) mice transplanted with human skin...
Harnessing the Participation of Dendritic Cells in Immunity and Tolerance
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Neutrophil Communication
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Psoriasis - Recent Advances in Diagnosis and Treatment
Psoriasis, a chronic autoinflammatory skin condition, significantly impacts quality of life. Its prevalence peaks at 2% in Northern countries. Thus, it is imperative to examine what practitioners can discern from psoriatic patients, ranging from the typical chronic plaque psoriasis to other manifestations. Recognizing these signs promptly can bring relief to patients and ensure optimal support. Treatment decisions must strike a balance between benefits and side effects, with patient empowerment being crucial for them to manage their lives effectively. This book offers readers, regardless of their specialty, the chance to view psoriatic patients from a different perspective, acknowledging that these patients require more than just pharmacological interventions.
Fitzpatrick's Therapeutics: A Clinician's Guide to Dermatologic Treatment
Make real-time therapeutic decisions with confidence with this concise, authoritative guide to dermatologic conditions Fitzpatrick's Therapeutics is a valuable bedside tool to assist clinicians in the treatment of dermatological conditions. It's the perfect companion to the larger Fitzpatrick's Dermatology, Ninth Edition. Concise yet comprehensive, Fitzpatrick's Therapeutics provides comprehensive treatment options in tabular format for the range of dermatologic conditions. You'll find practical information for clinical practice, including dosing regimens, adverse effects, monitoring, and level of evidence based on the American Academy of Dermatology guidelines with annotated references. • Companion dermatologic treatment guide to Fitzpatrick's Dermatology, Ninth Edition • Convenient tabular format for quick reference • Annotated references • Concise summaries of treatment options with information on treatment modifications and monitoring • Content will be updated on AccessDermatologyDxRx as new FDA-approved drugs become available
Reconstructive Transplantation and Regenerative Medicine
This book summarizes rapid progress and innovation in transplantation and regenerative medicine - the merger of reconstructive plastic surgery and transplantation - called Vascularized Composite Allotransplantation. This merger includes face, hand, uteri, larynx, tongue, penis and trachea translplantations as well as other body part transplants using grafts derived from organ donors. These sorts of transplants are now performed more commonly. Cell therapies for immunomodulation are surrogates for immune responses after transplantation to non-invasive imaging of neuroregeneration for improving functional outcomes after transplant.
