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Adoptive T Cell Therapy Cures Mice from Active Hemophagocytic Lymphohistiocytosis (HLH)
Abstract: Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by impaired lymphocyte cytotoxicity. First-line therapeutic regimens directed against activated immune cells or secreted cytokines show limited efficacy since they do not target the underlying immunological problem: defective lymphocyte cytotoxicity causing prolonged immune stimulation. A potential rescue strategy would be the adoptive transfer of ex vivo gene-corrected autologous T cells. However, transfusion of cytotoxicity-competent T cells under conditions of hyperinflammation may cause more harm than benefit. As a proof-of-concept for adoptive T cell therapy (ATCT) under hyperinflammatory c...
Working Paper
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Parables of the Afterlife
A young woman's car breaks down, leaving her stranded alongside a country road. She sets out on foot to find help, only to wander into a real-world nightmare from which there is no escape--except one. She must make a choice--the single most difficult choice she could ever be made to make. Her decision will determine the fate of her immortal soul. A distinguished scholar discovers a vast library containing the sum of all human learning. It is his to enjoy for all eternity--but there is a catch. Is a man--any man--fit to live forever? He may have found the answer in an old book. But will he believe? He must make a choice--the single most difficult choice he could ever be made to make. His immortal soul hangs in the balance. C. S. Lewis famously said that in the end there are only two kinds of people: those who say to God, "Thy will be done," and those to whom God says, "Thy will be done." These stories are those words recast in parable form.
Coopers International Journal
Vols. -27, no. 5, -May 1918 include a section in German; the section from Feb. 1903-May 1918 has title: Die Internationale Küfer-Zeitung.
The Long Crisis
Low-income housing in crisis -- From renters to owners -- Remaking public parks -- Patrolling city streets -- The trouble with development -- The governance of homelessness and public space.
The Challenge of Public-private Partnerships
Análise comparativa sobre parceria público privada e contrato de serviço social nos seguintes locais: Reino Unido, Estados Unidos, Suécia, Dinamarca, Alemanha, Austrália, Ásia.
