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Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials
Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Behavioral and Cytological Differences Between Two Parkinson,Äôs Disease Experimental Models
The knowledge about the biochemical and behavioral changes in humans with PD has allowed proposing animal models for its study; however, the results obtained so far have been heterogeneous. Recently, we established a novel PD model in rodents by manganese chloride (MnCl2) and manganese acetate (Mn (OAc)3) mixture inhalation. After inhaling, the rodents presented bilateral loss of SNc dopaminergic neurons. Later, we conclude that the alterations are of dopamine origin since L-DOPA reverted the alterations. After six months, SNc significantly reduced the number of cells, and striatal dopamine content decreased by 71%. The animals had postural instability, action tremor, and akinesia; these sym...
Global Instability in the Elliptic Restricted Three Body Problem
The goal of this thesis is to show global instability or Arnold's diffusion in the elliptic restricted three body problem (ERTBP) by proving the existence of pseudo-trajectories diffusing along the phase space for certain ranges of the eccentricity of the primaries (e), the angular momentum of the comet (G) and the parameter of mass (μ). More precisely, the results presented in his thesis, are valid for G big enough, eG bounded and μ small enough. The thesis is divided in two chapters and two appendices. The chapter one, contains all the main results. After introducing the ERTBP, we use McGehee coordinates to define the infinity manifold, which turn to be a three dimensional invariant mani...
Annual Report
Includes reports of activities of: National Institute of Science and Technology, Philippine Atomic Energy Commission, Philippine Coconut Research Institute, Philippine Textile Research Institute, Philippine Inventors Commmission and Forest Products Research and Industries Development Commission.
Oxidative Stress and Chronic Degenerative Diseases
This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.
Advancing the Rights of the Girl-child in Elementary and Secondary Education
Papers presented at the Second International Conference on Human Rights and Peace and Conflict in Southeast Asia, 17-18 October 2012, held in Jakarta.
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