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Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials
Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Behavioral and Cytological Differences Between Two Parkinson,Äôs Disease Experimental Models
The knowledge about the biochemical and behavioral changes in humans with PD has allowed proposing animal models for its study; however, the results obtained so far have been heterogeneous. Recently, we established a novel PD model in rodents by manganese chloride (MnCl2) and manganese acetate (Mn (OAc)3) mixture inhalation. After inhaling, the rodents presented bilateral loss of SNc dopaminergic neurons. Later, we conclude that the alterations are of dopamine origin since L-DOPA reverted the alterations. After six months, SNc significantly reduced the number of cells, and striatal dopamine content decreased by 71%. The animals had postural instability, action tremor, and akinesia; these sym...
Melatonin Pretreatment Effect in a Parkinson Disease Experimental Model Induced by the Inhalation of Manganese in Mice
Parkinson disease (PD) is characterized by dopaminergic neuron loss of the substantia nigra compacta (SNc) and motor alterations. Here, we used the experimental model of inhalation of the mixture of manganese chloride (MnCl2) and manganese acetate Mn (OAc)3 for inducing PD. This model causes bilateral and progressive degeneration of the SNc dopaminergic neurons. Melatonin has antioxidant properties and it has been suggested that it contributes to the protective effect in neurodegenerative diseases. Therefore, we aimed to determine whether melatonin pretreatment protects against the Mn-induced alterations. Before Mn inhalation, three groups were trained for motor performance (1. control group...
Mexican Political Biographies, 1935-1993
My Father’s Shoes is, at its core, an anthology of short stories. The book is allegoric and the shoes are metaphoric. Unlike most anthologies, however, these stories are an amalgam of themselves. They integrate and coalesce. There is a rhythm and a cadence both in substance and in form. This book was initially written as a gift to my father. I wanted to share certain memories with him that were meaningful and lasting. I wanted him to know, from my perspective, just how important he was in my life. He never really understood the profound impact that he had on the lives of other people –especially his family. Because of that humility, or perhaps in honor of it, I wanted to him know that he...
Foreigners in the Homeland
Foreigners in the Homeland analyzes the reception of the Latin American Boom novel in Spain. It argues in favor of an expanded concept of national literature that is not restricted to the native production of citizens but also takes into consideration the importance and nationalization of foreign cultural products. Charting the courses of interliterary relations between Spain and Spanish America, the book analyzes the conditions of the literary market during the 1960s and 1970s, follows the appropriation and canonization of Latin American authors and texts by readers and writers, and examines their impact on the resurgence of regional literatures within Spanish territory.
International Joint Conference SOCO’14-CISIS’14-ICEUTE’14
This volume of Advances in Intelligent and Soft Computing contains accepted papers presented at SOCO 2014, CISIS 2014 and ICEUTE 2014, all conferences held in the beautiful and historic city of Bilbao (Spain), in June 2014. Soft computing represents a collection or set of computational techniques in machine learning, computer science and some engineering disciplines, which investigate, simulate, and analyze very complex issues and phenomena. After a through peer-review process, the 9th SOCO 2014 International Program Committee selected 31 papers which are published in these conference proceedings. In this relevant edition a special emphasis was put on the organization of special sessions. On...
Anti-Drug Policies in Colombia
Forty years after the declaration of the "war on drugs" by President Nixon, the debate on the effectiveness and costs of the ban is red-hot. Several former Latin American presidents and leading intellectuals from around the world have drawn attention to the ineffectiveness and adverse consequences of prohibitionism. This book thoroughly analyzes the drug policies of one of the main protagonists in this war. The book covers many topics: the economics of drug production, the policies to reduce consumption and decrease supply during the Plan Colombia, the effects of the drug problem on Colombia's international relations, the prevention of money laundering, the connection between drug trafficking and paramilitary politics, and strategies against organized crime. Beyond the diversity in topics, there is a common thread running through all the chapters: the need to analyze objectively what works and what does not, based on empirical evidence. Presented here for the first time to an English-speaking audience, this book is a contribution to a debate that urgently needs to transcend ideology and preconceived opinions.
Mexican American Baseball in the Pomona Valley
This volume pays homage to the wonderful teams and players from Azusa, La Verne, Claremont, Pomona, Chino, Cucamonga, Ontario, and Upland. A common thread of all these diverse communities was the establishment of baseball teams and, later, softball teams. Baseball played a critical role in advancing civil and political rights, labor reform, gender equality, educational integration, and cultural legitimacy. These remarkable photographs revive the often-overlooked history of Mexican American baseball in the Greater Pomona Valley.
