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A comprehensive review the state-of-the-art in atherosclerosis of the arteries of the legs and feet. The authors discuss in detail the primary symptom-claudication-an intermittent pain in the leg or foot while walking, its predisposing factors, the current diagnostic methodologies, the impressive advances in the therapeutic armamentarium, and the need to screen for co-existing coronary artery disease. Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug eluting stents for peripheral arterial disease. The authors also examine the epidemiology of LEAD, the effects of smoking and effective smoking cessation programs, its pathogenesis and its association with lipid abnormalities and hypertension, aggressive risk factor modification, and the need to measure the ankle brachial index of every patient over 45.
This is the eleventh in a series of evaluated sets of rate constants and photochemical cross sections compiled by the NASA Panel for Data Evaluation. The primary application of the data is in the modeling of stratospheric processes, with special emphasis on the ozone layer and its possible perturbation by anthropogenic and natural phenomena. Demore, W. B. and Sander, S. P. and Golden, D. M. and Hampson, R. F. and Kurylo, M. J. and Howard, C. J. and Ravishankara, A. R. and Kolb, C. E. and Molina, M. J. Jet Propulsion Laboratory NASA-CR-198863, JPL-PUBL-94-26, NAS 1.26:198863 NAS7-1260; RTOP 464-41-04-01-00...
Since 2008, the world has experienced an enormous decrease of wealth. By many measures the impact of the crisis was severe. The fall in GDP, the collapse of world trade, the rise in unemployment, and the credit slump reached bigger proportions than in any other crisis since World War II. Although the economic figures seem to improve in some countries, the crisis continues being a challenging issue and is said to be one of the most important problems governments face today. The crisis has put public finances under ever increasing pressure, and governments have responded through austerity measures such as new fiscal rules and budgeting procedures and cutbacks of public spending. Public Managem...
As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Rele...
This is an open access book. This book, the first edited collection of its kind, explores the recent emergence of philosophical research in astrophysics. It assembles a variety of original essays from scholars who are currently shaping this field, and it combines insightful overviews of the current state of play with novel, significant contributions. It therefore provides an ideal source for understanding the current debates in philosophy of astrophysics, and it offers new ideas for future cutting-edge research. The selection of essays offered in this book addresses methodological and metaphysical questions that target a wide range of topics, including dark matter, black holes, astrophysical observations and modelling. The book serves as the first standard resource in philosophy of astrophysics for all scholars who work in the field and want to expand or deepen their knowledge, but it also provides an accessible guide for all those philosophers and scientists who are interested in getting a first, basic understanding of the main issues in philosophy of astrophysics.
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Historical, statistical, biographical and bibliographical information about The Gambia, Africa and its leaders.