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Medical Biostatistics for Complex Diseases
A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. They are characterized by the systems properties of gene networks and their interrelations, instead of individual genes, whose malfunctioning manifests in pathological phenotypes, thus making the analysis of the resulting large data sets particularly challenging. This is why novel approaches are needed to tackle this problem efficiently on a systems level. Written by computational biologists and biostatisticians, this book is an invaluable resource for a large number of researchers working on basic but also applied aspects of biomedical data analysis emphasizing the pathway level.
Novel Therapeutic Concepts in Targeting Glioma
Novel Therapeutic Concepts for Targeting Glioma offers a comprehensive collection of current information and the upcoming possibilities for designing new therapies for Glioma by an array of experts ranging from Cell Biologists to Oncologists and Neurosurgeons. A variety of topics cover therapeutic strategies based on Cell Signaling, Gene Therapy, Drug Therapy and Surgical methods providing the reader with a unique opportunity to expand and advance his knowledge of the field.
Gene Expression and Regulation in Mammalian Cells
"Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.
Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases
Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to media...
Tumors of the Central Nervous system, Volume 3
The classification of brain tumors is up-dated using magnetic resonance spectroscopy technology. The role of cellular immortality in brain tumors is reviewed. Tumor to tumor metastases are a common occurrence; for example, , brain metastasis from breast cancer, lung cancer, and renal cancer is discussed. Genetic profiling and treatment (including neurosurgery) of such brain cancers are explained. Breast cancer patients treated with certain drugs (e.g., capecitabine and lapatinib can develop CNS tumors. Role of brain tumor suppressor genes (e.g., NRP/B gene) is pointed out. Biomarkers used to diagnose brain malignancies are explained in detail. A number of imaging modalities used for diagnosing and assessing the effectiveness of treatments of brain tumors are presented. The imaging methods discussed include MRI, PET, CT, MRSi, and SPECT. Also, is discussed the impact of PET using radiolabeled amino acids on brain tumors.
HEALTH & SCIENCE 2022-IV
ARTIFICIAL INTELLIGENCE FOR CATARACT Furkan ÇİFTCİ ARTIFICIAL INTELLIGENCE FOR UVEITIS . Mustafa Suat ALIKMA POSSIBLE COMPLICATIONS OF GLAUCOMA SURGERY Çiğdem DENİZ GENÇ THE RELATIONSHIP BETWEEN INSOMNIA AND INJURY IN ATHLETES Semih KARAMAN ASSOCIATION BETWEEN MALNUTRITION AND MENTAL HEALTH IN THE ELDERLY Merve İLHAN ESGİN, Seda KAYA THE ROLE OF NUTRIENT INTAKE AND DIET IN IRRITABLE BOWEL SYNDROME Seda KAYA, Merve İLHAN ESGİN ACUTE ORGANOPHOSPHATE POISONING Şeyda KAPTAN CARCINOGENIC EFFECT OF NICOTINE Yakup ARSLAN THE EFFECTS OF DIFFERENT TOBACCO CONSUMPTION PATTERNS ON VITAL PARAMETERS OF DROSOPHILA MELANOGASTER Mehmet FİDAN, Arif AYAR PANCREAS: ANATOMY, VARIATION, CLINICAL AND SURGICAL PERSPECTIVE Şahi Nur KALKIŞIM, Özlem KANBER UZUN, Canan ERTEMOĞLU ÖKSÜZ
Edição Gênica por CRISPR/Cas9
Este livro foi elaborado por ex-alunos e colaboradores do Grupo NUCEL de Terapia Celular e Molecular da USP, com o objetivo de facilitar a compreensão e aplicação da técnica revolucionária de Edição Genética CRISPR/Cas9. Na parte introdutória, abordamos desde a descrição inicial do locus CRISPR (do inglês Clustered Regularly Interspaced Palindromic Repeats) até a descoberta do mecanismo de funcionamento e o desenvolvimento de formas adaptadas deste sistema para edição gênica direcionada e precisa do genoma de diversos organismos. Em seguida, apresentamos, detalhadamente, o passo a passo de como realizar uma edição gênica de maneira prática e confiável, através do sistema CRISPR/Cas9.
