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Edição Gênica por CRISPR/Cas9
Este livro foi elaborado por ex-alunos e colaboradores do Grupo NUCEL de Terapia Celular e Molecular da USP, com o objetivo de facilitar a compreensão e aplicação da técnica revolucionária de Edição Genética CRISPR/Cas9. Na parte introdutória, abordamos desde a descrição inicial do locus CRISPR (do inglês Clustered Regularly Interspaced Palindromic Repeats) até a descoberta do mecanismo de funcionamento e o desenvolvimento de formas adaptadas deste sistema para edição gênica direcionada e precisa do genoma de diversos organismos. Em seguida, apresentamos, detalhadamente, o passo a passo de como realizar uma edição gênica de maneira prática e confiável, através do sistema CRISPR/Cas9.
Proceedings of 2nd International Congress on Epigenetics & Chromatin 2017
November 06-08, 2017 Frankfurt, Germany Key Topics : Epigenetics, Epigenomics, Immunogenetics, Translational Epigenetics, Neurodevelopmental Disorders, Bioinformatics Development in Epigenetics, Epigenetics and Environmental Origins of Cancer, Epigenetic Diseases – Clinical Applications, Pharmacogenomics & Personalized Medicine, Genetic Disorders, Current Case studies/ Discussions: Epigenetics, Cancer Epigenetics, Epigenetics Inheritance, Epigenetic Regulation, Epigenetics Mechanism, Epigenetics Psychology, Epigenetics Factors, Epigenetics Therapy, Clinical Epigenetics, Epigenetics Markers, Epigenetics Methylation, Epigenetics Silencing, Epigenetics Alteration, Neuronal Epigenetics, Epigenetics and Nutrition, Reproductive Epigenetics, Animal Epigenetics, Plant Epigenetics, Medical Epigenetics,
Handbook of Research on Approaches to Alternative Entrepreneurship Opportunities
In some cases, technology-based projects have revolutionized the way of living by contributing to job and wealth creation. These types of ventures, regardless of their outstanding relevance, are the exception rather than the norm in that they account for only a very small percentage of entrepreneurial activity. Although not ignoring these important ventures, the main goal of this title is to fully unleash the wide potential of the entrepreneurial activity, exploring and highlighting the somewhat hidden part, which is ultimately responsible for the largest part of new businesses and, as a consequence, for the wellbeing of millions of people virtually everywhere. The Handbook of Research on Ap...
Computer Supported Qualitative Research
This book includes selecting the articles accepted for presentation and discussion at WCQR2021, held on January 20th to 22nd, 2021 (Virtual Conference). The World Conference on Qualitative Research (WCQR) is an annual event that aims to bring together researchers, academics and professionals, promoting the sharing and discussion of knowledge, new perspectives, experiences and innovations on Qualitative Research. WCQR2021 featured four main application fields (Education, Health, Social Sciences, and Engineering/Technology) and seven main subjects: Rationale and Paradigms of Qualitative Research; Systematization of Approaches with Qualitative Studies; Qualitative and Mixed Methods Research; Data Analysis Types; Innovative Processes of Qualitative Data Analysis; Qualitative Research in Web Context; Qualitative Analysis with Software Support. The book is a valuable resource for everyone interested in qualitative research, emphasizing Computer-Assisted Qualitative Data Analysis Software (CAQDAS).
Integrative Approaches to Sustainable Development at University Level
This book documents and compares the experiences of a wide range of universities across the five continents with regard to sustainable development, making it of special interest to sustainability researchers and practitioners. By showcasing how integrative approaches to sustainable development at the university level can be successfully employed to bridge the gaps between disciplines, the book provides a timely contribution to the literature on sustainability and offers a valuable resource for all those interested in sustainability in a higher education context.
Inhibitors of Protein–Protein Interactions
Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.
Universities as Living Labs for Sustainable Development
This book fills an important gap in the literature, and presents contributions from scientists and researchers working in the field of sustainable development who have engaged in dynamic approaches to implementing sustainability in higher education. It is widely known that universities are key players in terms of the implementation and further development of sustainability, with some having the potential of acting as “living labs” in this rapidly growing field. Yet there are virtually no publications that explore the living labs concept as it relates to sustainability, and in an integrated manner. The aims of this book, which is an outcome of the “4th World Symposium on Sustainable Dev...
Anticancer Agents
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, ...
Advances in Tourism, Technology and Systems
This book features a collection of high-quality research papers presented at the International Conference on Tourism, Technology & Systems (ICOTTS 2021), held at the University of Cartagena, in Cartagena de Indias, Colombia, from 4 to 6 November 2021. The book is divided into two volumes, and it covers the areas of technology in tourism and the tourist experience, generations and technology in tourism, digital marketing applied to tourism and travel, mobile technologies applied to sustainable tourism, information technologies in tourism, digital transformation of tourism business, e-tourism and tourism 2.0, big data and management for travel and tourism, geotagging and tourist mobility, smart destinations, robotics in tourism, and information systems and technologies.
Targeting Protein-Protein Interactions by Small Molecules
This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.
