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Este livro foi elaborado por ex-alunos e colaboradores do Grupo NUCEL de Terapia Celular e Molecular da USP, com o objetivo de facilitar a compreensão e aplicação da técnica revolucionária de Edição Genética CRISPR/Cas9. Na parte introdutória, abordamos desde a descrição inicial do locus CRISPR (do inglês Clustered Regularly Interspaced Palindromic Repeats) até a descoberta do mecanismo de funcionamento e o desenvolvimento de formas adaptadas deste sistema para edição gênica direcionada e precisa do genoma de diversos organismos. Em seguida, apresentamos, detalhadamente, o passo a passo de como realizar uma edição gênica de maneira prática e confiável, através do sistema CRISPR/Cas9.
São inúmeras as plantas com propriedades medicinais utilizadas como alternativas terapêuticas nas doenças crônicas, dentre elas, destacam-se as que possuem propriedades farmacológicas e que podem ser utilizadas no tratamento do diabetes mellitus. Além disso, muitas dessas plantas que são utilizadas como formas de tratamentos também são utilizadas como temperos na culinária popular. O presente livro tem como objetivo descrever as plantas utilizadas na culinária popular que possuem eficácia no auxílio ao tratamento do diabetes mellitus. Em virtude do acentuado aumento no número de indivíduos diagnosticados com diabetes mellitus, novas alternativas de tratamento estão sendo pes...
"Global health security, focused on a firefighting short-term response efforts fail to consider the differential impacts of outbreaks on women. For example, the policy response to the Zika outbreak centred on limiting the spread of the vector through civic participation and asking women to defer pregnancy. Both actions are inherently gendered and reveal a distinct lack of consideration of the everyday lives of women. These policies placed women in a position whereby were blamed if they had a child born with Congenital Zika Syndrome, and at the same time governments required women to undertake invisible labour for vector control. What does this tell us about the role of women in global health...
This book provides in-depth information on Caatinga’s geographical boundaries and ecological systems, including plants, insects, fishes, amphibians, reptiles, birds, and mammals. It also discusses the major threats to the region’s socio-ecological systems and includes chapters on climate change and fast and large-scale land-use changes, as well as slow and small-scale changes, also known as chronic human disturbances. Subsequent chapters address sustainable agriculture, conservation systems, and sustainable development. Lastly, the book proposes 10 major actions that could enable the transformation of Caatinga into a place where people and nature can thrive together. “I consider this b...
The treatment of inflammatory bowel disease (IBD) has posed a major challenge since its appearance. Biomedical researchers, physicians, gastroenterologists, and surgeons have struggled to improve the quality of life of their patients and have sought, above all else, to keep the disease under remission for as long as possible. Blockers for tumoral necrosis factor alpha (TNF-alpha) were the first biological drugs to be discovered and for this reason they played a crucial role in the subsequent evolution of IBD treatment. The aim of this book is to provide an overview of such drugs and the latest developments in IBD immunopathology. Our contributors discuss the main indications, efficacy, and possible side effects of the different types of drugs available today for IBD treatment.
A compilação dos textos traz filmes de diversos gêneros, países e gostos diferentes. De A Árvore da Vida , A Pele que Habito , As Aventuras de Tintim . Passando por Divã , Kinatay , O Contador de Histórias , etc. As críticas apresentam obras que estrearam nos cinemas e outras disponíveis em DVD e Blu-Ray. O livro aborda uma análise crítica de cinco anos em 50 resenhas cinematográficas, publicadas no Blog do Sergio Batisteli, entre 2007 a 2012 e em outros sites especializados em cinema. Página do livro no Facebook http://www.facebook.com/pages/5-Anos-em-50-Críticas-de-Cinema/365416870147178
'Investor Protection and Corporate Governance' analyzes the impact of corporate governance on firm performance and valuation. Using unique datasets gathered at the firm-level the first such data in the region and results from a homogeneous corporate governance questionnaire, the book examines corporate governance characteristics, ownership structures, dividend policies, and performance measures. The book's analysis reveals the very high levels of ownership and voting rights concentrations and monolithic governance structures in the largest samples of Latin American companies up to now, and new data emphasize the importance of specific characteristics of the investor protection regimes in several Latin American countries. By and large, those firms with better governance measures across several dimensions are granted higher valuations and thus lower cost of capital. This title will be useful to researchers, policy makers, government officials, and other professionals involved in corporate governance, economic policy, and business finance, law, and management.