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Science in early childhood
"In recent times, in nursery and primary schools, the introduction of organizing by environments or spaces of free choice has been widely extended, usually distributed in thematic areas of knowledge. This book aims to respond to the need to construct powerful science spaces from the point of view of learning while also maintaining the appeal and fascination that children feel for the phenomena of the natural world
Ciència des del néixer
En els darrers temps, a les escoles d'infantil i primària, s'ha estès àmpliament la introducció de l'organització per ambients o espais de lliure elecció, habitualment distribuïts en àmbits temàtics de coneixement. Aquest llibre vol donar resposta a la necessitat de construir espais de ciència potents des del punt de vista de l’aprenentatge i que alhora mantinguin l’atractiu i la fascinació que els infants senten pels fenòmens del món natural. Les 49 + 1 propostes d’aquest llibre sorgeixen de l’experiència obtinguda en el Lab 0_6, centre de descoberta, recerca i documentació per a l'educació científica a les primeres edats, de la Facultat de Ciències Socials de Manr...
Nucleic Acids Chemistry
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.
Drug Discovery and Development, Volume 1
From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development...
Target Discovery and Validation
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Thro...
NanoBioEngineering
The objective of this book is to provide the fundamental comprehension of a broad range of topics in an integrated volume such that readership hailing from diverse disciplines can rapidly acquire the necessary background for applying it in pertinent research and development field.
Photochromism: Molecules and Systems
Photochromism is simply defined as the light induced reversible change of colour. The field has developed rapidly during the past decade as a result of attempts to improve the established materials and to discover new devices for applications.As photochromism bridges molecular, supramolecular and solid state chemistry, as well as organic, inorganic and physical chemistry, such a treatment requires a multidisciplinary approach and a broad presentation. The first edition (1990) provided an enormous amount of new concepts and data, such as the presentation of main families based on the pericyclic reaction mechanism, the review of new families, some bimolecular photocycloadditions and some promi...
Design and Delivery of SiRNA Therapeutics
This volume details protocols on rationale design of therapeutic siRNA molecules and its encapsulation with smart vehicles to overcome the barriers to an effective administration in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Design and Delivery of SiRNA Therapeutics aims to ensure successful results in the further study of this vital field. This volume details protocols on rationale design of therapeutic ...
