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Experimental Therapeutics
As a general rule, for every 10,000 molecules screened in a given program in the laboratory, only one will survive to launch. To minimize costs, companies need to catch potential failures, due either to lack of clinical effect or toxicity, in the early discovery phase, long before they reach patients. Experimental Therapeutics introduces the dynamic and competitive discipline of experimental medicine. Informative, concise, and easy-to-read, the book emphasizes what scientists involved in drug discovery need to know about the rapid advances made in molecular biology, genetics, and technology. Each chapter starts with a summary box, has several high yield boxes, tables, and figures and ends with a reference section that has key URLs and carefully selected references to scientific papers. The book is a useful primer for anyone working to advance the pharmacological management of disease.
Pulmonary Hypertension: Mechanisms and Management, History and Future
We are grateful for the support of Actelion – a sponsor of this Research Topic – whose cooperation has contributed to fostering scientific discovery by reducing article publishing costs for some authors. We hereby state publicly that Actelion has had no editorial input in articles included in this research topic, thus ensuring that all aspects of this Research Topic were evaluated objectively, unbiased by any specific policy or opinion of Actelion. Actelion is part of the Johnson & Johnson Family of Companies. We are leaders in the science and medicine of pulmonary arterial hypertension (PAH), with over 15 years of experience in this devastating cardiovascular disorder.
Cardiovascular Pharmacogenetics
The Human Genome Project was sold to the general public largely on the basis that a complete picture of the structure of human DNA would lead to new and better medicines. These medicines would be better because they would be tailored to individual patients, maximising the chances of a therapeutic response and mi nimising the risks of an adverse event. Taking the idea further, pundits have pre dicted that the time will come when we could carry our DNA on a card which could be read rapidly and enable the physician to choose the best drug. This is the future. This is pharmacogenetics. When the draft human DNA sequence was announced and scientists were as ked how this would help drug development...
Cannabis and Cannabis-based Medicines
This report takes an objective look at the evidence on cannabis-based medicines and their ability to treat conditions such as multiple sclerosis and chronic pain.
Out of the Ashes
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Computer Animation Complete
A compilation of key chapters from the top MK computer animation books available today - in the areas of motion capture, facial features, solid spaces, fluids, gases, biology, point-based graphics, and Maya. The chapters provide CG Animators with an excellent sampling of essential techniques that every 3D artist needs to create stunning and versatile images. Animators will be able to master myriad modeling, rendering, and texturing procedures with advice from MK's best and brightest authors. Divided into five parts (Introduction to Computer Animation and Technical Background, Motion Capture Techniques, Animating Substances, Alternate Methods, and Animating with MEL for MAYA), each one focusi...
Pharmacotherapy of Pulmonary Hypertension
This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
Essentials of Lewis's Child and Adolescent Psychiatry
This companion handbook to the Fourth Edition of the renowned Lewis's Child and Adolescent Psychiatry offers 26 chapters of essential information, distilled from the larger text. Essentials of Lewis's Child and Adolescent Psychiatry features clinically relevant information on commonly seen disorders and includes key clinical points in expository format, supported by bulleted lists and tables. The early chapters focus on history, theory, and research methods along with normal development of children from infancy through adolescence. Table listings of disorders and drugs used to treat them allow quick and authoritative reference.
Diverse Results
Martin Steward, an American bacteriologist, isolates a strain of bacteria that poses a public health problem in the United States, and are considered candidate agents for bacteriological warfare. One of Dr. Steward's close acquaintances turns out to be a Soviet spy who murders a Fort Detrick scientist.
